Chaperone-mediated autophagy (CMA) is a lysosome-dependent selective degradation
pathway implicated in the pathogenesis of cancer and neurodegenerative diseases …

Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques,
neurofibrillary tangles, and neuronal loss, accompanied by neuroinflammation …

Chaperone-mediated autophagy (CMA) is a protein degradation mechanism through
lysosomes. By targeting the KFERQ motif of the substrate, CMA is responsible for the …

Background The neuropathological hallmarks of Alzheimer's disease (AD) are amyloid-β
(Aβ) plaques and neurofibrillary tangles (NFTs). The amyloid cascade theory is the leading …

Dysregulation of autophagy, a cellular catabolic mechanism essential for degradation of
misfolded proteins, has been implicated in multiple neurodegenerative diseases. However …

Alzheimer's disease (AD) is the most common neurodegenerative disease. The
accumulation of amyloid beta (Aβ) is the main pathology of AD. Metformin, a well‐known …

The evidence of strong pathological associations between type 2 diabetes and Alzheimer's
disease (AD) has increased in recent years. Contrary to suggestions that anti-diabetes drugs …

Autophagy malfunctioning occurs in multiple human disorders, making attractive the idea of
chemically modulating it with therapeutic purposes. However, for many types of autophagy …

Alzheimer's disease (AD) is an age‐related neurodegenerative disease, and the imbalance
between production and clearance of β‐amyloid (Aβ) is involved in its pathogenesis …

Autophagy is essential in regulating the turnover of macromolecules via removing damaged
organelles, misfolded proteins in various tissues, including liver, skeletal muscles, and …