Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures

A Herrmann - Chemical Society Reviews, 2014 - pubs.rsc.org
Reversible covalent bond formation under thermodynamic control adds reactivity to self-
assembled supramolecular systems, and is therefore an ideal tool to assess complexity of …

Dynamic combinatorial chemistry

JM Lehn, AV Eliseev - Science, 2001 - science.org
Combinatorial chemistry is now widely used to generate vast libraries of molecules that can
be screened for biologically active substances and new materials. In a parallel development …

Chemical biology of dynamic combinatorial libraries

O Ramström, T Bunyapaiboonsri, S Lohmann… - … et Biophysica Acta (BBA …, 2002 - Elsevier
Dynamic combinatorial chemistry (DCC) is a recently introduced supramolecular approach
to generate libraries of chemical compounds based on reversible exchange processes. The …

Dynamic combinatorial libraries: from exploring molecular recognition to systems chemistry

J Li, P Nowak, S Otto - Journal of the American Chemical Society, 2013 - ACS Publications
Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the
library members interconvert continuously by exchanging building blocks with each other …

Evolution of dynamic combinatorial chemistry

FBL Cougnon, JKM Sanders - Accounts of Chemical Research, 2012 - ACS Publications
Since its inception in the mid-1990s, dynamic combinatorial chemistry (DCC), the chemistry
of complex systems under thermodynamic control, has proved valuable in identifying …

Dynamic combinatorial chemistry: on the road to fulfilling the promise

S Ladame - Organic & Biomolecular Chemistry, 2008 - pubs.rsc.org
Dynamic combinatorial chemistry makes use of reversible reactions between functionalised
monomeric building blocks to generate a mixture of products (dimers or oligomers) under …

[图书][B] Dynamic combinatorial chemistry: in drug discovery, bioorganic chemistry, and materials science

BL Miller - 2009 - books.google.com
Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short
period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept …

Growing prospects of dynamic covalent chemistry in delivery applications

S Ulrich - Accounts of chemical research, 2019 - ACS Publications
Conspectus Delivery remains a major obstacle restricting the potential action of small
molecular drugs as well as novel biologics which cannot readily enter cells without the help …

Drug discovery by dynamic combinatorial libraries

O Ramström, JM Lehn - Nature Reviews Drug Discovery, 2002 - nature.com
Dynamic combinatorial chemistry is a recently introduced supramolecular approach that
uses self-assembly processes to generate libraries of chemical compounds. In contrast to …

Dynamic covalent synthesis

FBL Cougnon, AR Stefankiewicz, S Ulrich - Chemical Science, 2024 - pubs.rsc.org
Dynamic covalent synthesis aims to precisely control the assembly of simple building blocks
linked by reversible covalent bonds to generate a single, structurally complex product. In …