It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

Disorders of metabolism affect multiple systems throughout the body, but may have the
greatest impact on both central and peripheral nervous systems. Current available …

Compelling evidence indicates that the mammalian target of rapamycin (mTOR) signaling
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …

Non-communicable diseases (NCDs) that involve neurodegenerative disorders and
metabolic disease impact over 400 million individuals globally. Interestingly, metabolic …

Significance: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder and
represents one of the most disabling conditions. AD shares many features in common with …

The mechanistic (or mammalian) target of rapamycin (mTOR) and the adenosine
monophosphate-activated protein kinase (AMPK) regulate cell survival and metabolism in …

Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

Impairment of energy metabolism is a hallmark of brain aging and several
neurodegenerative diseases, such as the Alzheimer's disease (AD). Age-and disease …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …