Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

Q Wu - International Journal of Molecular Sciences, 2023 - mdpi.com
Endometrial decidualization is a uterine process essential for spiral artery remodeling,
embryo implantation, and trophoblast invasion. Defects in endometrial decidualization and …

ANP promotes HTR‐8/SVneo cell invasion by upregulating protein kinase N 3 via autophagy inhibition

N Chu, Y Tang, CJ Wang, JN Pei, SL Luo… - The FASEB …, 2023 - Wiley Online Library
Preeclampsia is a gestational disease characterized by two major pathological changes‐
shallow trophoblast invasion and impaired spiral artery remodeling. Atrial natriuretic peptide …

Investigating the effects of atrial natriuretic peptide on the maternal endothelium to determine potential implications for preeclampsia

NK Binder, S Beard, N de Alwis, BR Fato… - International Journal of …, 2023 - mdpi.com
Preeclampsia is associated with an increased lifelong risk of cardiovascular disease (CVD).
It is not clear whether this is induced by persistent systemic organ and vascular damage …

Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia

Y Gu, D Thompson, J Xu, DF Lewis, JA Morgan… - Pregnancy …, 2018 - Elsevier
Objective Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to
atrial natriuretic peptide (ANP), a cardiac hormone that regulates salt-water balance and …

ANXA4 promotes trophoblast invasion via the PI3K/Akt/eNOS pathway in preeclampsia

Y Xu, L Sui, B Qiu, X Yin, J Liu… - American Journal of …, 2019 - journals.physiology.org
The inadequate trophoblast invasion is associated with the development of preeclampsia
(PE). Considering that annexin A4 (ANXA4) enhances tumor invasion, we aimed to explore …

Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling

W Zhang, S Li, J Lou, H Li, M Liu… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Atrial natriuretic peptide (ANP) is an important hormone in cardiovascular biology. It is
activated by the protease corin. In pregnancy, ANP and corin promote uterine spiral artery …

Administration of the PARP Inhibitor Pj34 Ameliorates the Impaired Vascular Function Associated With Enos−/− Mice

FA English, FP Mccarthy, IJ Andersson… - Reproductive …, 2012 - journals.sagepub.com
A low-resistance/high-flow uteroplacental circulation is integral to a healthy pregnancy.
Impaired flow in the uterine circulation is associated with intrauterine growth restriction …

The potential role of pregnancy-associated plasma protein-A2 in angiogenesis and development of preeclampsia

X Chen, K Chen, Y Feng, C Ren, W Li, J Xiao… - Hypertension …, 2019 - nature.com
Compromised placentation strongly predisposes to preeclampsia (PE) which is a severe
complication of pregnancy. Pregnancy-associated plasma protein-A2 (PAPP-A2) has higher …

[HTML][HTML] Is Atrial Natriuretic Peptide (ANP) and Natriuretic Peptide Receptor-A (NPR-A) Expression in Human Placenta and Decidua Normal?

H Tan, L Lin, L Huang, Y Yu - Medical science monitor …, 2019 - ncbi.nlm.nih.gov
Background Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood
pressure and the salt-water balance in the blood. It acts through natriuretic peptide receptors …

CLDN1 regulates trophoblast apoptosis and proliferation in preeclampsia

Y Zhang, X Qin, X Ma, H Mo, S Qin, C Zhang… - …, 2021 - rep.bioscientifica.com
Preeclampsia is a gestational hypertensive disease; however, preeclampsia remains poorly
understood. Bioinformatics analysis was applied to find novel genes involved in the …