Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

Macrophages and dendritic cells are myeloid cells that play critical roles in immune
responses. Macrophages help to maintain homeostasis through tissue regeneration and the …

Immune cells can sense and respond to biophysical cues—from dynamic forces to spatial
features—during their development, activation, differentiation and expansion. These …

Cells in the human body experience and integrate a wide variety of environmental cues. A
growing interest in tissue mechanics in the past four decades has shown that the …

The importance of innate immune cells to sense and respond to their physical environment
is becoming increasingly recognized. Innate immune cells (eg macrophages and …

T cells are key players of the mammalian adaptive immune system. They experience
different mechanical microenvironments during their life cycle, from the thymus, secondary …

Macrophages perform critical functions for homeostasis and immune defense in tissues
throughout the body. These innate immune cells are capable of recognizing and clearing …

In recent years, biomaterial-and scaffold-based immunomodulation strategies were
implemented in tissue regeneration efforts for manipulating macrophage polarization (aka …

Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …

Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This
structural plasticity, which facilitates their migration and communicative function, also …