The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent
kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and …

Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …

Introduction: Intensive efforts, over the last decade, have been made to inhibit the kinase
activity of cyclins that act as mediators during cell-cycle progression. Activation of the cyclin …

Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer
and is a biomarker of cancer phenotype and disease progression. The ability of these …

Cyclin D1 integrates extracellular signals by coupling signals from cell surface receptors to
transcription factors, thereby regulating diverse gene expression networks. Cyclin D1 has …

The proto-oncogene cyclin D1 has been implicated in the genesis of a large proportion of
human tumors from diverse histological origins. It has long been assumed that the action of …

The mammalian cell cycle is driven by a complex of cyclins and their associated cyclin-
dependent kinases (CDKs). Abnormal dysregulation of cyclin-CDK is a hallmark of cancer. D …

Perturbations in the regulation of the core cell cycle machinery are frequently observed in
human cancers. Cyclin D1 which functions as a mitogenic sensor and allosteric activator of …

D cyclins include three isoforms: D1, D2, and D3. D cyclins heterodimerize with cyclin-
dependent kinase 4/6 (CDK4/6) to form kinase complexes that can phosphorylate and …

Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular
substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis …