Purpose To determine whether augmented renal clearance (ARC) impacts negatively on
piperacillin-tazobactam unbound concentrations in critically ill patients receiving 16 g/2 …

This prospective pharmacokinetic study aimed to compare the clearance of piperacillin-
tazobactam administered as a 24-h continuous infusion between continuous venovenous …

Objectives To evaluate the pharmacokinetics of piperacillin/tazobactam in critically ill
patients undergoing continuous renal replacement therapy (CRRT) and to assess the …

In the critical care setting, augmented renal clearance (ARC) is increasingly recognized as
one of the leading causes of subtherapeutic antibiotic exposure [1]. However, commonly …

Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …

This study examined the effect of various levels of renal impairment on the probability of
achieving free drug concentrations that exceed the MIC for 50% of the dosing interval (50% f …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

Results Sixty-eight participants had data for analysis. Regardless of infusion duration, 6 g/d
piperacillin was associated with≤ 45% target attainment, whereas 12 g/d was associated …

Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …

Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …