The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis.
Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in …

Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Renal fibrosis is the common end point of virtually all progressive kidney diseases. Renal
fibrosis should not be viewed as a simple and uniform'scar', but rather as a dynamic system …

Regardless of etiology, all patients with chronic renal disease show a progressive decline in
renal function with time. Fibrosis, so-called scarring, is a key cause of this pathophysiology …

Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost
all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of
renal survival. Many different cell types contribute to TIF progression including tubular …

Although the kidney has capacity to repair after mild injury, ongoing or severe damage
results in scarring (fibrosis) and an associated progressive loss of kidney function. However …

The year 2015 has seen great progress in the renal fibrosis field, as key studies began to
build a consensus on the importance of epithelial-to-mesenchymal transition, cell cycle …

Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of
pathological matrix in the interstitial space and within the walls of glomerular capillaries as …