Role of LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) as a cardiovascular risk predictor: mechanistic insight and potential clinical use
J Barreto, SK Karathanasis, A Remaley… - … , and vascular biology, 2021 - Am Heart Assoc
Atherosclerosis, the underlying cause of cardiovascular disease (CVD), is a worldwide
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease
A Akhmedov, T Sawamura, CH Chen… - European heart …, 2021 - academic.oup.com
Cardiovascular diseases (CVDs), specifically lipid-driven atherosclerotic CVDs, remain the
number one cause of death worldwide. The lectin-like oxidized low-density lipoprotein (LDL) …
number one cause of death worldwide. The lectin-like oxidized low-density lipoprotein (LDL) …
Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders
JL Mehta, J Chen, PL Hermonat, F Romeo… - Cardiovascular …, 2006 - academic.oup.com
Abstract LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …
LOX-1 the multifunctional receptor underlying cardiovascular dysfunction
S Ogura, A Kakino, Y Sato, Y Fujita, S Iwamoto… - Circulation …, 2009 - jstage.jst.go.jp
Oxidatively modified low-density lipoprotein (oxLDL) is implicated in the pathogenesis of
atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces …
atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces …
Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives
Abstract LOX‐1 (lectin‐like oxidized low‐density lipoprotein receptor‐1; also known as
OLR1) is the dominant receptor that recognizes and internalizes oxidized low‐density …
OLR1) is the dominant receptor that recognizes and internalizes oxidized low‐density …
Lectin‐like oxidized low‐density lipoprotein receptor‐1, a new promising target for the therapy of atherosclerosis?
Endothelial activation and dysfunction induced by oxidized modified low‐density lipoprotein
(ox‐LDL) is one of the key steps in the initiation of atherosclerosis. Recent studies have …
(ox‐LDL) is one of the key steps in the initiation of atherosclerosis. Recent studies have …
Contribution of lectin-like oxidized low-density lipoprotein receptor-1 and LOX-1 modulating compounds to vascular diseases
A Hofmann, C Brunssen, H Morawietz - Vascular pharmacology, 2018 - Elsevier
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for
binding and uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells. LOX-1 is …
binding and uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells. LOX-1 is …
LOX-1 in atherosclerosis and myocardial ischemia: biology, genetics, and modulation
NVK Pothineni, SK Karathanasis, Z Ding… - Journal of the American …, 2017 - jacc.org
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), one of the scavenger
receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the …
receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the …
The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease
S Dunn, RS Vohra, JE Murphy… - Biochemical …, 2008 - portlandpress.com
Scavenger receptors are membrane glycoproteins that bind diverse ligands including lipid
particles, phospholipids, apoptotic cells and pathogens. LOX-1 (lectin-like oxidized low …
particles, phospholipids, apoptotic cells and pathogens. LOX-1 (lectin-like oxidized low …
LOX-1-mediated effects on vascular cells in atherosclerosis
DA Chistiakov, AN Orekhov… - Cellular Physiology and …, 2016 - karger.com
In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-
1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly …
1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly …
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