Organismal aging and oxidants beyond macromolecules damage

MV Clement, L Luo - Proteomics, 2020 - Wiley Online Library
The relationship between oxidants and organismal aging was first articulated through the
free radical theory of aging. One of the major predictions of the free radical theory of aging is …

Oxidative damage and age-related functional declines

I Martin, MS Grotewiel - Mechanisms of ageing and development, 2006 - Elsevier
Most organisms experience progressive declines in physiological function as they age.
Since this senescence of function is thought to underlie the decrease in quality of life in …

Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?

AB Salmon, A Richardson, VI Pérez - Free Radical Biology and Medicine, 2010 - Elsevier
The oxidative stress theory of aging predicts that manipulations that alter oxidative
stress/damage will alter aging. The gold standard for determining whether aging is altered is …

Redox biology of aging: focus on novel biomarkers

KB Pandey, SI Rizvi - Free Radicals in Human Health and Disease, 2015 - Springer
Oxidative stress-mediated damage to functional macromolecules followed by their
accumulation has been reported as a major factor behind aging and related consequences …

[HTML][HTML] Happily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

A Höhn, D Weber, T Jung, C Ott, M Hugo, B Kochlik… - Redox biology, 2017 - Elsevier
Aging is a complex phenomenon and its impact is becoming more relevant due to the rising
life expectancy and because aging itself is the basis for the development of age-related …

Role of oxidative stress in aging

D Knoefler, HL Tienson, U Jakob - Oxidative Stress and Redox Regulation, 2013 - Springer
The question of why we age has given rise to many different theories over the last decades.
One of the most popular and long-lasting hypothesis is the free radical theory of aging. It …

A comprehensive review of biochemical and molecular evidences from animal and human studies on the role of oxidative stress in aging: an epiphenomenon or the …

S Momtaz, M Abdollahi - 2012 - repository.up.ac.za
Aging is an undeniable fact shadowing animal life but while it comes to human, aging affects
all aspects of their physical and emotional abilities. Aging occurs by multi-stimuli which is …

Oxidative stress in aging: advances in proteomic approaches

D Ortuño-Sahagún, M Pallàs… - … Medicine and Cellular …, 2014 - Wiley Online Library
Aging is a gradual, complex process in which cells, tissues, organs, and the whole organism
itself deteriorate in a progressive and irreversible manner that, in the majority of cases …

Oxidative stress in the aging process: fundamental aspects and new insights

L Gil del Valle, R Gravier Hernández… - … , and Therapy Volume …, 2015 - ACS Publications
Aging researches have experienced an unprecedented advance over recent years. The
comprehension of process leading to age-associated alterations is at moment of the highest …

Revisiting an age-old question regarding oxidative stress

YH Edrey, AB Salmon - Free Radical Biology and Medicine, 2014 - Elsevier
Significant advances in maintaining health throughout life can be made through a clear
understanding of the fundamental mechanisms that regulate aging. The Oxidative Stress …