Understanding keloid pathobiology from a quasi-neoplastic perspective: less of a scar and more of a chronic inflammatory disease with cancer-like tendencies

S Tan, N Khumalo, A Bayat - Frontiers in immunology, 2019 - frontiersin.org
Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of
the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids …

The keloid disorder: heterogeneity, histopathology, mechanisms and models

GC Limandjaja, FB Niessen, RJ Scheper… - Frontiers in cell and …, 2020 - frontiersin.org
Keloids constitute an abnormal fibroproliferative wound healing response in which raised
scar tissue grows excessively and invasively beyond the original wound borders. This …

Keloids–clinical diagnosis, pathogenesis, and treatment options: Keloide–klinische Diagnose, Pathogenese und Behandlungsoptionen

AG Marneros, T Krieg - JDDG: Journal der Deutschen …, 2004 - Wiley Online Library
Keloids are defined as excessive scar tissue formation extending beyond the area of the
original skin injury and occurring in predisposed individuals. They are considered to be a …

Keloids: The paradigm of skin fibrosis—Pathomechanisms and treatment

JP Andrews, J Marttala, E Macarak, J Rosenbloom… - Matrix Biology, 2016 - Elsevier
Keloids, fibroproliferative dermal tumors with effusive accumulation of extracellular matrix
(ECM) components, particularly collagen, result from excessive expression of growth factors …

Systemic factors that shape cutaneous pathological scarring

C Huang, R Ogawa - The FASEB Journal, 2020 - Wiley Online Library
Cutaneous pathological scars are fibrotic lesions that grow continuously, invade the
adjacent skin, and are erythematous, itchy, and painful. Their etiology remains unclear but …

[HTML][HTML] Keloid pathophysiology: fibroblast or inflammatory disorders?

FW Nangole, GW Agak - JPRAS open, 2019 - Elsevier
Background Keloids are defined as a benign dermal fibroproliferative disorder with no
malignant potential. They tend to occur following trivial trauma or any form of trauma in …

Functional histopathology of keloid disease

N Jumper, R Paus, A Bayat - 2015 - digitum.um.es
Keloid disease is a benign, yet locally aggressive and recurrent cutaneous fibroproliferative
condition characterised by excessive scarring. Unique to humans, keloids represent the end …

Keloid‐derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology

JM Hahn, K Glaser, KL McFarland… - Wound Repair and …, 2013 - Wiley Online Library
Keloids are disfiguring scars that extend beyond the original wound borders and resist
treatment. Keloids exhibit excessive extracellular matrix deposition, although the underlying …

Downregulated cytotoxic CD8+ T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids

H Xu, Z Zhu, J Hu, J Sun, Y Wo, X Wang… - Cellular & Molecular …, 2022 - nature.com
Keloids are an abnormal fibroproliferative wound-healing disease with a poorly understood
pathogenesis, making it difficult to predict and prevent this disease in clinical settings …

Site‐specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates

R Bagabir, RJ Byers, IH Chaudhry… - British Journal of …, 2012 - academic.oup.com
Background Keloid disease (KD) is a common fibroproliferative disorder of unknown
aetiology. T cells and macrophages are increased in KD and are thought to contribute to its …