Rotavirus A genome segments show distinct segregation and codon usage patterns

I Hoxie, JJ Dennehy - Viruses, 2021 - mdpi.com
Reassortment of the Rotavirus A (RVA) 11-segment dsRNA genome may generate new
genome constellations that allow RVA to expand its host range or evade immune responses …

Intragenic recombination influences rotavirus diversity and evolution

I Hoxie, JJ Dennehy - Virus evolution, 2020 - academic.oup.com
Because of their replication mode and segmented dsRNA genome, homologous
recombination is assumed to be rare in the rotaviruses. We analyzed 23,627 complete …

Analysis of human rotaviruses from a single location over an 18-year time span suggests that protein coadaption influences gene constellations

S Zhang, PW McDonald, TA Thompson… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT Rotaviruses (RVs) are 11-segmented, double-stranded RNA viruses that cause
severe gastroenteritis in children. In addition to an error-prone genome replication …

Evolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellations

SM McDonald, J Matthijnssens, JK McAllen… - PLoS …, 2009 - journals.plos.org
Group A human rotaviruses (RVs) are a major cause of severe gastroenteritis in infants and
young children. Yet, aside from the genes encoding serotype antigens (VP7; G-type and …

[HTML][HTML] Rotavirus diversity and evolution in the post-vaccine world

JT Patton - Discovery medicine, 2012 - ncbi.nlm.nih.gov
Rotaviruses (RVs) are a large genetically diverse population of segmented double-stranded
(ds) RNA viruses that are important causes of gastroenteritis in many animal species. The …

Comparative genomic analysis of genogroup 1 and genogroup 2 rotaviruses circulating in seven US cities, 2014–2016

MD Esona, R Gautam, E Katz, J Jaime, ML Ward… - Virus …, 2021 - academic.oup.com
For over a decade, the New Vaccine Surveillance Network (NVSN) has conducted active
rotavirus (RVA) strain surveillance in the USA. The evolution of RVA in the post-vaccine …

Strain-Specific Interactions between the Viral Capsid Proteins VP4, VP7 and VP6 Influence Rescue of Rotavirus Reassortants by Reverse Genetics

R Valusenko-Mehrkens, AK Gadicherla… - International Journal of …, 2023 - mdpi.com
Rotavirus A (RVA) genome segments can reassort upon co-infection of target cells with two
different RVA strains. However, not all reassortants are viable, which limits the ability to …

Genetic determinants restricting the reassortment of heterologous NSP2 genes into the simian rotavirus SA11 genome

R Mingo, S Zhang, CP Long, LEW LaConte… - Scientific Reports, 2017 - nature.com
Rotaviruses (RVs) can evolve through the process of reassortment, whereby the 11 double-
stranded RNA genome segments are exchanged among strains during co-infection …

Analysis of codon usage pattern evolution in avian rotaviruses and their preferred host

JJ Kattoor, YS Malik, A Sasidharan, VM Rajan… - Infection, Genetics and …, 2015 - Elsevier
Rotavirus infection is a worldwide problem, with occurrence of highly divergent viruses
classified in 8 species (A–H). We report here the evolution assessment of codon usage …

Rotavirus rearranged genomic RNA segments are preferentially packaged into viruses despite not conferring selective growth advantage to viruses

C Troupin, A Schnuriger, S Duponchel, C Deback… - PLoS …, 2011 - journals.plos.org
The rotavirus (RV) genome consists of 11 double-stranded RNA segments. Sometimes,
partial sequence duplication of an RNA segment leads to a rearranged RNA segment. To …