There has been a long debate about the predominant involvement of the different adenosine
receptor subtypes and the preferential role of pre‐versus post‐synaptic mechanisms in the …

Caffeine is the most consumed psychoactive drug in the world. It is a non-selective
adenosine receptor antagonist that in the brain targets mainly adenosine A 1 and A 2A …

[Frontiers in Bioscience 13, 2391-2399, January 1, 2008] 2391 Adenosine A1-A2A receptor
heteromers: new targets for caffeine in Page 1 [Frontiers in Bioscience 13, 2391-2399, January …

Caffeine is the most widely consumed psychostimulant substance, being self-administered
throughout a wide range of conditions and present in numerous dietary products. Due to its …

Dopamine has been proposed to mediate some of the behavioral effects of caffeine. This
review discusses cellular mechanisms of action that could explain the role of dopamine in …

The popularity of caffeine as a psychoactive drug is due to its stimulant properties, which
depend on its ability to reduce adenosine transmission in the brain. Adenosine A 1 and A 2A …

Adenosine, by acting on adenosine A1 and A2A receptors, exerts opposite modulatory roles
on striatal extracellular levels of glutamate and dopamine, with activation of A1 inhibiting …

Previous studies have demonstrated opposing roles for adenosine A1 and A2A receptors in
the modulation of extracellular levels of glutamate and dopamine in the striatum. In the …

Background The psychostimulant properties of caffeine are reviewed and compared with
those of prototypical psychostimulants able to cause substance use disorders (SUD) …

Caffeine, a potent central stimulant, is known to competitively inhibit the specific binding of
both adenosine and benzodiazepine receptor ligands to brain membranes in vitro. In mice …