[HTML][HTML] Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice
J Go, TS Park, GH Han, HY Park… - International …, 2018 - spandidos-publications.com
Piperlongumine (PL), a biologically active compound from the Piper species, has been
shown to exert various pharmacological effects in a number of conditions, including tumours …
shown to exert various pharmacological effects in a number of conditions, including tumours …
Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats
S Ma, S Xu, B Liu, J Li, N Feng, L Wang… - … archives of pharmacology, 2009 - Springer
It is shown that l-3-n-butylphthalide (l-NBP), the isomer of dl-NBP (racemic 3-n-
butylphthalide, a new anti-cerebral ischemic agent) significantly attenuated cerebral …
butylphthalide, a new anti-cerebral ischemic agent) significantly attenuated cerebral …
Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the …
J Xu, S Rong, B Xie, Z Sun, Q Deng… - … Series A: Biomedical …, 2010 - academic.oup.com
The major purpose of this study was to determine the effects of procyanidins extracted from
the lotus seedpod on cAMP-response element-binding protein phosphorylation in …
the lotus seedpod on cAMP-response element-binding protein phosphorylation in …
[HTML][HTML] The improving effect of HL271, a chemical derivative of metformin, a popular drug for type II diabetes mellitus, on aging-induced cognitive decline
E Bang, B Lee, JO Park, Y Jang, A Kim… - Experimental …, 2018 - ncbi.nlm.nih.gov
In recent years, as the aging population grows, aging-induced cognitive impairments
including dementia and Alzheimer's disease (AD) have become the biggest challenges for …
including dementia and Alzheimer's disease (AD) have become the biggest challenges for …
Triptolide rescues spatial memory deficits and amyloid-β aggregation accompanied by inhibition of inflammatory responses and MAPKs activity in APP/PS1 transgenic …
YQ Cui, Q Wang, DM Zhang, JY Wang… - Current Alzheimer …, 2016 - ingentaconnect.com
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease characterized by
aggregation of amyloid-β (Aβ) peptide in the hippocampus and cortex of brain …
aggregation of amyloid-β (Aβ) peptide in the hippocampus and cortex of brain …
Lamivudine improves cognitive decline in SAMP8 mice: Integrating in vivo pharmacological evaluation and network pharmacology
M Li, J Zhao, Q Tang, Q Zhang, Y Wang… - Journal of Cellular …, 2021 - Wiley Online Library
The reverse transcriptase inhibitors such as lamivudine (3TC) play important roles in anti‐
ageing, but their effects on neurodegenerative diseases caused by ageing are not clear …
ageing, but their effects on neurodegenerative diseases caused by ageing are not clear …
[HTML][HTML] Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment
Y Xie, A Song, Y Zhu, A Jiang, W Peng, C Zhang… - Biomedicine & …, 2021 - Elsevier
Background In the present study, we aimed to investigate the effects of probucol on aging-
related hippocampus-dependent cognitive impairment and explore the potential …
related hippocampus-dependent cognitive impairment and explore the potential …
Mahanimbine improved aging-related memory deficits in mice through enhanced cholinergic transmission and suppressed oxidative stress, amyloid levels, and …
Murraya koenigii leaves contain mahanimbine, a carbazole alkaloid, reported with
improving cholinergic neuronal transmission and reducing neuroinflammation in the CNS …
improving cholinergic neuronal transmission and reducing neuroinflammation in the CNS …
Long-Term DL-3-n-Butylphthalide Treatment Alleviates Cognitive Impairment Correlate With Improving Synaptic Plasticity in SAMP8 Mice
C Lv, Q Ma, B Han, J Li, Y Geng, X Zhang… - Frontiers in Aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent form of dementia worldwide. AD is
characterized by mild cognitive impairment at onset, irreversibly progressing with age to …
characterized by mild cognitive impairment at onset, irreversibly progressing with age to …
DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss
W Zhou, W Lian, R Yan, H Jia, L Xu, L Wang… - Acta Pharmacologica …, 2020 - nature.com
At present, few available drugs can be used to either improve pathological features or
prevent the progression of Alzheimer's disease (AD). DL0410 ((1, 1′-([1, 1′-biphenyl]-4 …
prevent the progression of Alzheimer's disease (AD). DL0410 ((1, 1′-([1, 1′-biphenyl]-4 …
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