We aimed to determine how age‐associated changes in mechanisms extrinsic and intrinsic
to pacemaker cells relate to basal beating interval variability (BIV) reduction in vivo. Beating …

The combined influences of sinoatrial nodal (SAN) pacemaker cell automaticity and its
response to autonomic input determine the heart's beating interval variability and mean …

A progressive decline in maximum heart rate (mHR) is a fundamental aspect of aging in
humans and other mammals. This decrease in mHR is independent of gender, fitness, and …

Background A reduction of complexity of heart beating interval variability that is associated
with an increased morbidity and mortality in cardiovascular disease states is thought to …

Objective The aim of this study was to assess age-related changes in cardiac autonomic
modulation and heart rate variability (HRV) and their association with spontaneous and …

An inexorable decline in maximum heart rate (mHR) progressively limits human aerobic
capacity with advancing age. This decrease in mHR results from an age-dependent …

Background Because of the complexity of the interaction between the internal pacemaker
mechanisms, cell interconnected signals, and interaction with other body systems, study of …

The normal heart beat intervals are neither strictly stationary nor completely random, and
continuously shift from one period to another. Decoding the ECG identifies this “hidden” …

Background Heart rate variability (HRV) is determined by intrinsic sinoatrial node (SAN)
activity and the autonomic nervous system (ANS). HRV is reduced in aging; however, aging …

Age-related deterioration of pacemaker function has been documented in mammals,
including humans. In aged isolated sinoatrial node tissues and cells, reduction in the …