A high prevalence of thrombotic disorders, insufficient effectiveness or safety of
antithrombotic therapy is an urgent problem of modern healthcare. The main means of …

Acetylsalicylic acid and its derivatives have different types of biological activity, including
antiaggregation, and are used as medications (for example, aspirin, DL-Lysine …

According to the current understanding, the hyperactivation of platelets may lead to
increased intravascular coagulation and thrombosis. Today a relevant issue is the search for …

Globally, cardio-cerebrovascular diseases caused by platelet aggregation pose a grave
threat to human health, and hence, research on anti-platelet aggregation is of paramount …

Heparin is a life-saving drug, which belongs to few clinically used drugs without defined
molecular structures in modern medicine. Heparin is the mostly negatively charged …

Abstract A series of (2 S, 4 S)-4-amino-N-arylpyroglutamic acids was first obtained by the
nucleophilic substitution of bromine atom in dimethyl (2 S, 4 RS)-4-bromo-N …

The purpose of the study was to develop methods for the synthesis of salts of 2-[3-methyl-8-
morpholino-7-(thietanyl-3) xanthinyl-1] acetic acid, to study their effect on the hemostatic …

A series of new 1, 3, 4-thiadiazine derivatives have been synthesized and their effect on the
human platelet aggregation in vitro has been studied. All the tested substances inhibit the …

Thiourea derivatives are widely studied and used as the most important reagents in organic
synthesis, as well as biologically active substances and drugs in medicine [1, 2]. One such …

To date, coumaric oral anticoagulants are the worldwide standard for thrombosis treatment.
However, representatives of this group also possess a number of undesirable side effects; …