[HTML][HTML] Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside
Y Liu, Y Wang, S Sun, Z Chen, S Xiang, Z Ding… - … hematology & oncology, 2022 - Springer
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …
also participates in the development and progression of cancer. In recent decades …
[HTML][HTML] Revisiting the roles of pro-metastatic EpCAM in cancer
Epithelial cell adhesion molecule (EpCAM) is a cell surface protein that was discovered as a
tumour marker of epithelial origins nearly four decades ago. EpCAM is expressed at basal …
tumour marker of epithelial origins nearly four decades ago. EpCAM is expressed at basal …
[HTML][HTML] Biology and clinical relevance of EpCAM
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily
known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression …
known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression …
EpCAM in carcinogenesis: the good, the bad or the ugly
BTF van der Gun, LJ Melchers, MHJ Ruiters… - …, 2010 - academic.oup.com
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly
expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic …
expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic …
The emerging role of EpCAM in cancer and stem cell signaling
M Munz, PA Baeuerle, O Gires - Cancer research, 2009 - AACR
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion
molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface …
molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface …
[HTML][HTML] Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?
O Gires, M Pan, H Schinke, M Canis… - Cancer and Metastasis …, 2020 - Springer
EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …
[HTML][HTML] Current view on EpCAM structural biology
A Gaber, B Lenarčič, M Pavšič - Cells, 2020 - mdpi.com
EpCAM, a carcinoma cell-surface marker protein and a therapeutic target, has been
primarily addressed as a cell adhesion molecule. With regard to recent discoveries of its role …
primarily addressed as a cell adhesion molecule. With regard to recent discoveries of its role …
EpCAM and its potential role in tumor-initiating cells
S Imrich, M Hachmeister, O Gires - Cell adhesion & migration, 2012 - Taylor & Francis
Epithelial cell adhesion molecule EpCAM is expressed on a subset of normal epithelia and
overexpressed on malignant cells from a variety of different tumor entities. This …
overexpressed on malignant cells from a variety of different tumor entities. This …
EpCAM duality becomes this molecule in a new Dr. Jekyll and Mr. Hyde tale
A Herreros-Pomares, C Aguilar-Gallardo… - Critical Reviews in …, 2018 - Elsevier
EpCAM, known as an epithelial cell adhesion molecule, plays an essential role in cell
adhesion, migration, metastasis and cell signalling. Rather than acting as an apoptosis …
adhesion, migration, metastasis and cell signalling. Rather than acting as an apoptosis …
[HTML][HTML] Functional implications of the dynamic regulation of EpCAM during epithelial-to-mesenchymal transition
TC Brown, NV Sankpal, WE Gillanders - Biomolecules, 2021 - mdpi.com
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein expressed in
epithelial tissues. EpCAM forms intercellular, homophilic adhesions, modulates epithelial …
epithelial tissues. EpCAM forms intercellular, homophilic adhesions, modulates epithelial …