The thesis work described here has been done as a full time Ph. D. candidate under
supervision of Prof. Dr. Hideyoshi Harashima, Faculty of Advanced Pharmaceutical …

The thesis work described here has been done as a full time Ph. D. candidate under
supervision of Prof. Dr. Hideyoshi Harashima, Faculty of Advanced Pharmaceutical …

An active targeting drug delivery system that targets the nucleus could solve the problem of
the treatment of genetic disorders through gene delivery, but it has met with limited success …

ABSTRACT Introduction: As 'chemical antibodies', aptamers have some advantages, such
as lack of immunogenicity, rapid tissue penetration, cell internalization and so on …

A novel modified nucleic acid nanoparticle harboring an annexin A2 aptamer for ovarian
cancer cell targeting and a GC rich sequence for doxorubicin loading is designed and …

Targeted delivery of therapeutic drugs and imaging agents remains a promising option in
the treatment and diagnosis of ovarian cancer. We have developed a new class of affinity …

In vivo selection of the RNA aptamers by systematic evolution of ligands by exponential
enrichment (SELEX) has demonstrated a great targeting tool for diagnostics and treatments …

The recent advances in molecular imaging techniques, using cancer-targeting nanoparticle
probes, provide noninvasive tracking information on cancer cells in living subjects. Here, we …

Targeted Delivery of therapeutic drugs and imaging agents, using nanoparticles, shows
great promise in diverse fields, including the diagnostics and treatment of cancer …

An in vitro-transcribed RNA aptamer (trans-RA16) that targets non-small cell lung cancer
(NSCLC) was previously identified through in vivo SELEX. Trans-RA16 can specifically …