[HTML][HTML] Cartilage oligomeric matrix protein, diseases, and therapeutic opportunities

J Cui, J Zhang - International journal of molecular sciences, 2022 - mdpi.com
Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that
is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic …

Cartilage oligomeric matrix protein: COMPopathies and beyond

KL Posey, F Coustry, JT Hecht - Matrix Biology, 2018 - Elsevier
Cartilage oligomeric matrix protein (COMP) is a large pentameric glycoprotein that interacts
with multiple extracellular matrix proteins in cartilage and other tissues. While, COMP is …

The role of cartilage oligomeric matrix protein (COMP) in skeletal disease

KL Posey, JT Hecht - Current drug targets, 2008 - ingentaconnect.com
Cartilage oligomeric matrix protein is a non-collagenous extracellular matrix protein
expressed primarily in cartilage, ligament, and tendon. Cartilage oligomeric matrix protein …

Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth

L Kong, Q Tian, F Guo, MT Mucignat, R Perris, S Sercu… - Matrix Biology, 2010 - Elsevier
In an effort to define the biological functions of COMP, a functional genetic screen was
performed. This led to the identification of extracellular matrix protein 1 (ECM1) as a novel …

Cartilage oligomeric matrix protein acts as a molecular biomarker in multiple cancer types

B Guo, Y Wang, W Liu, S Zhang - Clinical and Translational Oncology, 2023 - Springer
Purpose The main function of cartilage oligomeric matrix protein (COMP) is to maintain the
synthesis and stability of the extracellular matrix by interacting with collagen. At present …

[HTML][HTML] Secretion of cartilage oligomeric matrix protein is affected by the signal peptide

P Holden, DR Keene, GP Lunstrum… - Journal of Biological …, 2005 - ASBMB
Cartilage oligomeric matrix protein (COMP) is a secreted glycoprotein found in the
extracellular matrices of skeletal tissues. Mutations associated with two human skeletal …

[HTML][HTML] Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis

S Koelling, TS Clauditz, M Kaste, N Miosge - Arthritis research & therapy, 2006 - Springer
As a member of the thrombospondin gene family, cartilage oligomeric protein (COMP) is
found mainly in the extracellular matrix often associated with cartilage tissue. COMP exhibits …

[HTML][HTML] Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis

E Englund, G Canesin, KS Papadakos, N Vishnu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cartilage oligomeric matrix protein (COMP) was recently implicated in the progression of
breast cancer. Immunostaining of 342 prostate cancer specimens in tissue microarrays …

[HTML][HTML] Effect of cartilage oligomeric matrix protein on mesenchymal chondrogenesis in vitro

J Kipnes, AL Carlberg, GA Loredo, J Lawler… - Osteoarthritis and …, 2003 - Elsevier
Objective: Cartilage oligomeric matrix protein (COMP) mutations have been identified as
responsible for two arthritic disorders, multiple epiphyseal dysplasia (MED) and …

Analysis of the promoter region of human cartilage oligomeric matrix protein (COMP)

M Deere, CR Hall, KB Gunning, V LeFebvre, AL Ridall… - Matrix Biology, 2001 - Elsevier
Cartilage oligomeric matrix protein (COMP) is an extracellular matrix protein expressed in
cartilage, ligament, and tendon. The importance of COMP in the matrix of these cells is …