[HTML][HTML] Cartilage oligomeric matrix protein, diseases, and therapeutic opportunities
J Cui, J Zhang - International journal of molecular sciences, 2022 - mdpi.com
Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that
is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic …
is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic …
Cartilage oligomeric matrix protein: COMPopathies and beyond
Cartilage oligomeric matrix protein (COMP) is a large pentameric glycoprotein that interacts
with multiple extracellular matrix proteins in cartilage and other tissues. While, COMP is …
with multiple extracellular matrix proteins in cartilage and other tissues. While, COMP is …
The role of cartilage oligomeric matrix protein (COMP) in skeletal disease
Cartilage oligomeric matrix protein is a non-collagenous extracellular matrix protein
expressed primarily in cartilage, ligament, and tendon. Cartilage oligomeric matrix protein …
expressed primarily in cartilage, ligament, and tendon. Cartilage oligomeric matrix protein …
Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth
In an effort to define the biological functions of COMP, a functional genetic screen was
performed. This led to the identification of extracellular matrix protein 1 (ECM1) as a novel …
performed. This led to the identification of extracellular matrix protein 1 (ECM1) as a novel …
Cartilage oligomeric matrix protein acts as a molecular biomarker in multiple cancer types
B Guo, Y Wang, W Liu, S Zhang - Clinical and Translational Oncology, 2023 - Springer
Purpose The main function of cartilage oligomeric matrix protein (COMP) is to maintain the
synthesis and stability of the extracellular matrix by interacting with collagen. At present …
synthesis and stability of the extracellular matrix by interacting with collagen. At present …
[HTML][HTML] Secretion of cartilage oligomeric matrix protein is affected by the signal peptide
P Holden, DR Keene, GP Lunstrum… - Journal of Biological …, 2005 - ASBMB
Cartilage oligomeric matrix protein (COMP) is a secreted glycoprotein found in the
extracellular matrices of skeletal tissues. Mutations associated with two human skeletal …
extracellular matrices of skeletal tissues. Mutations associated with two human skeletal …
[HTML][HTML] Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis
S Koelling, TS Clauditz, M Kaste, N Miosge - Arthritis research & therapy, 2006 - Springer
As a member of the thrombospondin gene family, cartilage oligomeric protein (COMP) is
found mainly in the extracellular matrix often associated with cartilage tissue. COMP exhibits …
found mainly in the extracellular matrix often associated with cartilage tissue. COMP exhibits …
[HTML][HTML] Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis
Cartilage oligomeric matrix protein (COMP) was recently implicated in the progression of
breast cancer. Immunostaining of 342 prostate cancer specimens in tissue microarrays …
breast cancer. Immunostaining of 342 prostate cancer specimens in tissue microarrays …
[HTML][HTML] Effect of cartilage oligomeric matrix protein on mesenchymal chondrogenesis in vitro
J Kipnes, AL Carlberg, GA Loredo, J Lawler… - Osteoarthritis and …, 2003 - Elsevier
Objective: Cartilage oligomeric matrix protein (COMP) mutations have been identified as
responsible for two arthritic disorders, multiple epiphyseal dysplasia (MED) and …
responsible for two arthritic disorders, multiple epiphyseal dysplasia (MED) and …
Analysis of the promoter region of human cartilage oligomeric matrix protein (COMP)
M Deere, CR Hall, KB Gunning, V LeFebvre, AL Ridall… - Matrix Biology, 2001 - Elsevier
Cartilage oligomeric matrix protein (COMP) is an extracellular matrix protein expressed in
cartilage, ligament, and tendon. The importance of COMP in the matrix of these cells is …
cartilage, ligament, and tendon. The importance of COMP in the matrix of these cells is …