Older individuals represent a growing population, in industrialized countries, particularly
those with cardiovascular diseases, which remain the leading cause of death in western …

Physical activity is considered one of the most powerful life-style interventions to promote
healthy ageing (Sallis, 2015). However, older adults rarely meet the recommended levels of …

Abstract Savla, Jainy J., Benjamin D. Levine, and Hesham A. Sadek. The effect of hypoxia
on cardiovascular disease: Friend or foe? High Alt Med Biol. 19: 124–130, 2018.—Over 140 …

Hypoxia and its corollaries pose both negative and positive pressures to multicellular
eukaryotes. Evolutionarily, life developed under hypoxia, and the building blocks were …

Hypoxia exists when O2 is delivered to the tissues at a partial pressure lower than that for
nonnal individuals of the same species at sea level. Because the partial pressure of O2 in …

Matthew E. Pamenter and Daniel Munro www. aging-us. com AGING 2019, Vol. 11, No. 16
www. aging-us. com 5864 AGING then there may be a correlation between …

Aging-related hypoxia, oxidative stress, and inflammation pathophysiology are closely
associated with human age-related carcinogenesis and chronic diseases. However, the …

Oxygen is vital for cellular metabolism; therefore, the hypoxic conditions encountered at high
altitude affect all physiological functions. Acute hypoxia activates the adrenergic system and …

Abstract Levine, Benjamin D. Going high with heart disease: The effect of high altitude
exposure in older individuals and patients with coronary artery disease. High Alt Med Biol …

Key points• A previous study showed that an older age could be associated with a lower risk
of severe altitude‐induced diseases.• This work combines a cross‐sectional study including …