Clinically, it is well known that chronic pain induces depression, anxiety, and a reduced
quality of life. There have been many reports on the relationship between pain and emotion …

Clinically, it has been reported that chronic pain induces depression, anxiety, and reduced
quality of life. The endogenous opioid system has been implicated in nociception, anxiety …

BACKGROUND: Chronic pain is clinically associated with the development of affective
disorders. However, studies in animal models of neuropathic pain are contradictory and the …

Clinical studies show that anxiety and chronic pain are concomitant. The neural basis for the
comorbidity is unclear. The prefrontal cortex (PFC) has been recognized as a critical area for …

BACKGROUND: Patients with chronic pain frequently suffer affective disorders, particularly
anxiety and depression. Although clinical research on the relationship between pain and …

Pain is considered a multidimensional conscious experience that includes a sensory
component and a negative affective-motivational component. The negative affective …

Depression and anxiety are common comorbidities of neuropathic pain (NP).
Pharmacological preclinical studies on NP have given abundant information on the effects of …

Although it has been accepted that depression and pain are common comorbidities, their
interaction is not fully understood. The present study was aimed to investigate the effects of …

Mood disorders and chronic pain are closely linked, but limited progress has been made in
understanding the role of chronic and neuropathic pain in the aetiopathogenesis of …

Abstract Pain was reported by 60–90% of patients with depression, and chronic pain states
are often linked to depression. Animal models of pain/depression are generally lacking for …