Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer's Coordinating Center database
DC Woodworth, KM Nguyen, L Sordo… - Acta …, 2024 - Springer
TDP-43 proteinopathy is a salient neuropathologic feature in a subset of frontotemporal
lobar degeneration (FTLD-TDP), in amyotrophic lateral sclerosis (ALS-TDP), and in limbic …
lobar degeneration (FTLD-TDP), in amyotrophic lateral sclerosis (ALS-TDP), and in limbic …
Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration
Abstract TAR-DNA binding protein-43 (TDP-43) proteinopathy is seen in multiple brain
diseases. A standardized terminology was recommended recently for common age-related …
diseases. A standardized terminology was recommended recently for common age-related …
Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies
Abstract TAR DNA-binding protein-43 (TDP-43) accumulation is the primary pathology
underlying several neurodegenerative diseases. Charting the progression and …
underlying several neurodegenerative diseases. Charting the progression and …
TDP-43 pathology and memory impairment in elders without pathologic diagnoses of AD or FTLD
Objective: To investigate the association of TAR DNA-binding protein 43 (TDP-43) pathology
with memory, other cognitive domains, and dementia in community-dwelling elders without …
with memory, other cognitive domains, and dementia in community-dwelling elders without …
Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and …
Abstract TAR-DNA binding protein 43 (TDP-43) proteinopathy is a common brain pathology
in elderly persons, but much remains to be learned about this high-morbidity condition …
in elderly persons, but much remains to be learned about this high-morbidity condition …
[HTML][HTML] TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration
Transactive response DNA-binding protein of∼ 43 kDa (TDP-43), a primary pathologic
substrate in tau-negative frontotemporal lobar degeneration (FTLD), is also often found in …
substrate in tau-negative frontotemporal lobar degeneration (FTLD), is also often found in …
[HTML][HTML] Prevalence of TDP-43 proteinopathy in cognitively normal older adults: systematic review and meta-analysis
C Nascimento, ATDL Alho, CBC Amaral… - Neuropathology and …, 2018 - ncbi.nlm.nih.gov
Objective To perform a systematic review and meta-analysis on the prevalence of TDP-43
proteinopathy in cognitively normal older adults. Methods We systematically reviewed and …
proteinopathy in cognitively normal older adults. Methods We systematically reviewed and …
Staging TDP-43 pathology in Alzheimer's disease
KA Josephs, ME Murray, JL Whitwell, JE Parisi… - Acta …, 2014 - Springer
Abstract TDP-43 immunoreactivity occurs in 19–57% of Alzheimer's disease (AD) cases.
Two patterns of TDP-43 deposition in AD have been described involving hippocampus …
Two patterns of TDP-43 deposition in AD have been described involving hippocampus …
TDP-43 pathology in the setting of intermediate and high Alzheimer's disease neuropathologic changes: A preliminary evaluation across ethnoracial groups
EZ Huie, A Escudero, N Saito, D Harvey… - Journal of …, 2023 - content.iospress.com
Background: Transactive Response DNA Binding Protein 43 kDa (TDP-43) pathology is
frequently found in cases with Alzheimer's disease (AD). TDP-43 pathology is associated …
frequently found in cases with Alzheimer's disease (AD). TDP-43 pathology is associated …
Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy
To better understand clinical and neuropathological features of TDP-43 proteinopathies,
data were analyzed from autopsied research volunteers who were followed in the National …
data were analyzed from autopsied research volunteers who were followed in the National …