Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades
Mitochondrial uncoupling protein 1 (UCP1) is essential for nonshivering thermogenesis in
brown adipose tissue and is widely accepted to have played a key thermoregulatory role in …
brown adipose tissue and is widely accepted to have played a key thermoregulatory role in …
[HTML][HTML] Evolution of UCP1 transcriptional regulatory elements across the mammalian phylogeny
MJ Gaudry, KL Campbell - Frontiers in physiology, 2017 - frontiersin.org
Uncoupling protein 1 (UCP1) permits non-shivering thermogenesis (NST) when highly
expressed in brown adipose tissue (BAT) mitochondria. Exclusive to placental mammals …
expressed in brown adipose tissue (BAT) mitochondria. Exclusive to placental mammals …
Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis
M Jastroch, KW Withers, S Taudien… - Physiological …, 2008 - journals.physiology.org
Brown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive
nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the …
nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the …
Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis
DA Hughes, M Jastroch, M Stoneking… - BMC evolutionary …, 2009 - Springer
Abstract Background Uncoupling protein 1 (UCP1) is a mitochondrial anion carrier,
expressed in brown adipose tissue (BAT) of Eutherians. UCP1 is responsible for uncoupling …
expressed in brown adipose tissue (BAT) of Eutherians. UCP1 is responsible for uncoupling …
Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis
Uncoupling proteins (UCPs) increase proton leakage across the inner mitochondrial
membrane. Thereby, UCP1 in brown adipose tissue dissipates proton motive force as heat …
membrane. Thereby, UCP1 in brown adipose tissue dissipates proton motive force as heat …
Here and there, but not everywhere: repeated loss of uncoupling protein 1 in amniotes
S McGaugh, TS Schwartz - Biology letters, 2017 - royalsocietypublishing.org
Endothermy is an evolutionary innovation in eutherian mammals and birds. In eutherian
mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although …
mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis (NST). Although …
Oxidative stress, thermogenesis and evolution of uncoupling proteins
The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic
mechanism. Recent work published in BMC Evolutionary Biology, following the identification …
mechanism. Recent work published in BMC Evolutionary Biology, following the identification …
Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals
S Saito, CT Saito, R Shingai - Gene, 2008 - Elsevier
Homeotherms possess various physiological mechanisms to maintain their body
temperature, thus allowing them to adapt to various environments. Under cold conditions …
temperature, thus allowing them to adapt to various environments. Under cold conditions …
Disruption of thermogenic UCP1 predated the divergence of pigs and peccaries
TJ Fyda, C Spencer, M Jastroch… - Journal of …, 2020 - journals.biologists.com
ABSTRACT Uncoupling protein 1 (UCP1) governs non-shivering thermogenesis in brown
adipose tissue. It has been estimated that pigs lost UCP1∼ 20 million years ago (MYA) …
adipose tissue. It has been estimated that pigs lost UCP1∼ 20 million years ago (MYA) …
Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB
JF Rahbani, J Bunk, D Lagarde, B Samborska… - Cell Metabolism, 2024 - cell.com
Summary That uncoupling protein 1 (UCP1) is the sole mediator of adipocyte thermogenesis
is a conventional viewpoint that has primarily been inferred from the attenuation of the …
is a conventional viewpoint that has primarily been inferred from the attenuation of the …