[HTML][HTML] Phospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors

J Dal Col, MJ Lamberti, A Nigro, V Casolaro… - Cell Communication and …, 2022 - Springer
Abstract Phospholipid scramblase 1 (PLSCR1) is the most studied protein of the scramblase
family. Originally, it was identified as a membrane protein involved in maintaining plasma …

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor

J Sun, M Nanjundan, LJ Pike, T Wiedmer, PJ Sims - Biochemistry, 2002 - ACS Publications
We have identified physical and functional interactions between the epidermal growth factor
(EGF) receptor and phospholipid scramblase 1 (PLSCR1), an endofacial plasma membrane …

[HTML][HTML] Identification of three new members of the phospholipid scramblase gene family

T Wiedmer, Q Zhou, DY Kwoh, PJ Sims - Biochimica et Biophysica Acta …, 2000 - Elsevier
Phospholipid (PL) scramblase is a 35 kDa protein that is thought to mediate Ca2+-induced
bidirectional transbilayer movement of plasma membrane phospholipids in activated …

[HTML][HTML] Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis

D Smrz, P Lebduska, J Korb, P Dráber - Journal of Biological Chemistry, 2008 - ASBMB
Phosphatidylserine (PS) in quiescent cells is predominantly confined to the inner leaflet of
the plasma membrane. Externalization of PS is a marker of apoptosis, exocytosis, and some …

Phospholipid scramblases: an overview

SK Sahu, SN Gummadi, N Manoj… - Archives of biochemistry …, 2007 - Elsevier
Phospholipid scramblases are a group of homologous proteins that are conserved in all
eukaryotic organisms. They are believed to be involved in destroying plasma membrane …

Phospholipid scramblase 1.

Y Huang, Q Zhao, GQ Chen - Sheng li xue bao:[Acta Physiologica …, 2006 - europepmc.org
Phospholipid scramblase 1 (PLSCR1) is a calcium-binding, multiply palmitoylated type II
endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import …

Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane

T Wiedmer, J Zhao, M Nanjundan, PJ Sims - Biochemistry, 2003 - ACS Publications
Phospholipid scramblase 1 (PLSCR1) is a Ca2+-binding, endofacial plasma membrane
protein thought to contribute to the transbilayer movement of phosphatidylserine and other …

[HTML][HTML] Phospholipid scramblase 1 modulates FcR-mediated phagocytosis in differentiated macrophages

C Herate, G Ramdani, NJ Grant, S Marion, S Gasman… - PLoS …, 2016 - journals.plos.org
Phospholipid Scramblase 1 (PLSCR1) was initially characterized as a type II
transmembrane protein involved in bilayer movements of phospholipids across the plasma …

[HTML][HTML] N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases

S Rayala, VG Francis, U Sivagnanam… - Journal of Biological …, 2014 - ASBMB
Human phospholipid scramblase 1 (hPLSCR1), a type II integral class membrane protein, is
known to mediate bidirectional scrambling of phospholipids in a Ca 2+-dependent manner …

Phospholipid Scramblase 1 Is Imported into the Nucleus by a Receptor-Mediated Pathway and Interacts with DNA,

I Ben-Efraim, Q Zhou, T Wiedmer, L Gerace… - Biochemistry, 2004 - ACS Publications
Phospholipid scramblase 1 (PLSCR1) is a multiply palmitoylated, Ca2+-binding, endofacial
plasma membrane protein originally identified by its capacity to accelerate transbilayer …