In 10 healthy normotensive volunteers on a normal sodium diet, we evaluated the renal
effects of a single oral dose of 50 mg of irbesartan (SR 47436, BMS 186295), an angiotensin …

We investigated the short-term and sustained hormonal and renal effects of angiotensin II
(Ang II) receptor blockade in normotensive healthy volunteers. Twenty-four subjects …

We studied the hemodynamic, neurohumoral, and biochemical effects of the novel
angiotensin type 1 (AT1) receptor antagonist irbesartan in 86 untreated patients with …

Objective The goal of this study was to investigate whether angiotensin II receptor blockers
(ARBs) induce a comparable blockade of AT 1 receptors in the vasculature and in the kidney …

We examined the renal hemodynamic modifications induced by a selective angiotensin II
(AII) AT1 receptor antagonist, losartan, in 10 patients with essential hypertension. In this …

Studies were conducted to determine whether pharmacokinetics of irbesartan (IRBE), a
potent, long-acting angiotensin (AT)-II receptor antagonist selective for AT-II type 1 receptor …

The intrarenal renin-angiotensin system plays a critical role in the paracrine regulation of
renal function and the pathophysiology of hypertension. Angiotensin II (AngII) is formed …

Abstract Irbesartan (SR 47436, BMS 186295) is an imidazole derivative that specifically
binds to the angiotensin type 1 receptor. The purpose of this study was to assess the …

Angiotensin II (AII) is a potent vasoconstrictor which, at physiological plasma concentrations,
produces antinatriuresis, whereas high intrarenal concentrations cause natriuresis and …

1 Experiments were performed using the selective AT1 receptor antagonist, GR117289, and
the selective AT2 receptor antagonist, PD123177, to assess the relative importance of AT1 …