The hypothalamus and pituitary essentially function as a unit. Thyrotropin-releasing
hormones, derived from the hypothalamus, stimulate thyrotropin release from the anterior …

B. Thyroid-binding proteins and free hormone. Thyroid hormone exists in circulation in both
free (or unbound) and bound forms. The amount of free hormone, which is the metabolically …

Advances in the measurement of thyroid gland function have often introduced new concepts
which led to the development of analogous diagnostic procedures in other areas of clinical …

THE thyroid gland captures iodide from the circulation against a gradient and rapidly
incorporates it into tyrosine to form mono-or diiodotyrosine. The iodinated tyrosines interact …

Millions of radioimmunoassays(RIA) for thyroid hor-. mones are performed annually in
clinical chemistry laboratories and in laboratories devoted to screening for congenital …

As described elsewhere in this issue, there are a sufficient number of measures of thyroid
function to enable the clinician to establish a diagnosis of thyroid disease with a high degree …

Publisher Summary This chapter discusses methods for thyroid hormone measurements.
Thyroxine (T 4), the main secretory product of the thyroid gland, is by far the most abundant …

Before 1950, clinicians depended on physical examination and clinical symptoms to
diagnose thyroid disorders. The introduction of the first thyroid test in the 1950s allowed an …

Thyroid function tests may be divided into four main groups (Table 1) by means of which one
tries to measure the hormone concentrationin the extrathyroidal hormone compartment, the …

Thyroid disease has a high prevalence in Western countries, being of the order of 1 to 3%.
I.'Most of the symptoms and most of the signs of thyroid disease are common to numerous …