Biodegradable composite scaffolds incorporating an intramedullary rod and delivering bone morphogenetic protein-2 for stabilization and bone regeneration in …

AM Henslee, PP Spicer, DM Yoon, MB Nair… - Acta biomaterialia, 2011 - Elsevier
In this study, a two-part bone tissue engineering scaffold was investigated. The scaffold
consists of a solid poly (propylene fumarate)(PPF) intramedullary rod for mechanical support …

Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2

TMG Chu, SJ Warden, CH Turner, RL Stewart - Biomaterials, 2007 - Elsevier
Segmental defect regeneration has been a clinical challenge. Current tissue-engineering
approach using porous biodegradable scaffolds to delivery osteogenic cells and growth …

Osteoblast growth and bone‐healing response to three‐dimensional poly (ε‐caprolactone fumarate) scaffolds

J Kim, A Sharma, B Runge, H Waters… - Journal of tissue …, 2012 - Wiley Online Library
Abstract Poly (ε‐caprolactone fumarate)(PCLF) scaffold formulations were assessed as a
delivery system for recombinant human bone morphogenetic protein (rhBMP‐2) for bone …

Optimized bone regeneration based on sustained release from three‐dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP‐2

YC Fu, H Nie, ML Ho, CK Wang… - Biotechnology and …, 2008 - Wiley Online Library
Contemporary treatment of critical bone defect remains a significant challenge in the field of
orthopedic surgery. Engineered biomaterials combined with growth factors have emerged …

Effect of different sustained bone morphogenetic protein‐2 release kinetics on bone formation in poly (propylene fumarate) scaffolds

MGL Olthof, DHR Kempen, JL Herrick… - … Research Part B …, 2018 - Wiley Online Library
To investigate the effect of sustained bone morphogenetic protein‐2 (BMP‐2) release
kinetics on bone formation in poly (propylene fumarate)(PPF) scaffolds, different poly (lactic …

Effect of calcium phosphate coating and rhBMP-2 on bone regeneration in rabbit calvaria using poly (propylene fumarate) scaffolds

M Dadsetan, T Guda, MB Runge, D Mijares… - Acta biomaterialia, 2015 - Elsevier
Various calcium phosphate based coatings have been evaluated for better bony integration
of metallic implants and are currently being investigated to improve the surface bioactivity of …

The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres

G Wei, Q Jin, WV Giannobile, PX Ma - Biomaterials, 2007 - Elsevier
It is advantageous to incorporate controlled growth factor delivery into tissue engineering
strategies. The objective of this study was to develop a three-dimensional (3D) porous tissue …

Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release

KV Brown, B Li, T Guda, DS Perrien… - … Engineering Part A, 2011 - liebertpub.com
Nonunion is a common complication in open fractures and other severe bone injuries.
Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on a collagen …

Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant

M Yoneda, H Terai, Y Imai, T Okada, K Nozaki, H Inoue… - Biomaterials, 2005 - Elsevier
Recombinant human bone morphogenetic protein (rhBMP)-2 in a block copolymer
composed of poly-d, l-lactic acid with randomly inserted p-dioxanone and polyethylene …

Three-dimensional printing of rhBMP-2-loaded scaffolds with long-term delivery for enhanced bone regeneration in a rabbit diaphyseal defect

JH Shim, SE Kim, JY Park, J Kundu, SW Kim… - … Engineering Part A, 2014 - liebertpub.com
In this study, recombinant human bone morphogenetic protein-2 (rhBMP-2) delivery system
with slow mode was successfully developed in three-dimensional (3D) printing-based …