Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

F Bonacina, D Coe, G Wang, MP Longhi… - Nature …, 2018 - nature.com
Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show
that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell …

Apolipoprotein E modulates immune activation by acting on the antigen‐presenting cell

C Tenger, X Zhou - Immunology, 2003 - Wiley Online Library
Apolipoprotein E (ApoE) is synthesized by a variety of cells including macrophages. These
cells activate T lymphocytes by antigen presentation, while the T‐cell cytokine, interferon‐γ …

Altered immune responses in apolipoprotein E-deficient mice

DT Laskowitz, DM Lee, D Schmechel, HF Staats - Journal of lipid research, 2000 - ASBMB
Apolipoprotein E (apoE) is a 34 kDa glycosylated protein with multiple biological properties.
In addition to its role in cholesterol transport, apoE has in vitro immunomodulatory …

Apolipoprotein E restricts interleukin-dependent T lymphocyte proliferation at the G1A/G1B boundary

MJ Mistry, MA Clay, ME Kelly, MA Steiner… - Cellular …, 1995 - Elsevier
Apolipoprotein E (apoE), a lipid transport protein important in cholesterol homeostasis,
inhibits the proliferation of interleukin-dependent lymphocytes. Growth factor-responsive …

Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice

DJ Grainger, J Reckless, E McKilligin - The Journal of Immunology, 2004 - journals.aai.org
Apolipoprotein E (apoE) is a 34-kDa glycoprotein involved in lipoprotein transport through
interaction with the low-density lipoprotein receptor and related receptors. Recently, it has …

The immune‐modulatory role of apolipoprotein E with emphasis on multiple sclerosis and experimental autoimmune encephalomyelitis

HL Zhang, J Wu, J Zhu - Journal of Immunology Research, 2010 - Wiley Online Library
Apolipoprotein E (apoE) is a 34.2 kDa glycoprotein characterized by its wide tissue
distribution and multiple functions. The nonlipid‐related properties of apoE include …

Acute loss of apolipoprotein E triggers an autoimmune response that accelerates atherosclerosis

M Centa, KE Prokopec, MG Garimella… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Dyslipidemia is a component of the metabolic syndrome, an established risk
factor for atherosclerotic cardiovascular disease, and is also observed in various …

The role of Apolipoprotein E in Guillain‐Barré syndrome and experimental autoimmune neuritis

H Zhang, J Wu, J Zhu - BioMed Research International, 2010 - Wiley Online Library
Apolipoprotein E (apoE) is a 34.2 kDa glycosylated protein characterized by its wide tissue
distribution and multiple functions. ApoE has been widely studied in lipid metabolism …

Cross‐talk between apolipoprotein E and cytokines

H Zhang, LM Wu, J Wu - Mediators of inflammation, 2011 - Wiley Online Library
Apolipoprotein E (apoE) is a multifunctional glycosylated protein characterized by its wide
tissue distribution. Despite its importance in lipid transport and atherosclerosis …

Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages.

P Cullen, A Cignarella, B Brennhausen… - The Journal of …, 1998 - Am Soc Clin Investig
In this study, we investigated the impact of the common apoE polymorphism on apoE
metabolism and cholesterol homeostasis in monocyte-derived macrophages isolated from …