A signaling pathway by which calcium influx regulates the expression of the major activity-
dependent transcript of BDNF in cortical neurons has been elucidated. Deletion and …

Activity‐dependent changes in synaptic strength, which appear to underlie cortical plasticity,
require long‐lasting biochemical changes in the postsynaptic neuron. An inductive event …

CREB is a transcription factor implicated in the control of adaptive neuronal responses.
Although one function of CREB in neurons is believed to be the regulation of genes whose …

Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated in a calcium-
and neuron-selective manner; however, the mechanisms that underlie this selectivity are not …

Plasticity is a remarkable feature of the brain, allowing neuronal structure and function to
accommodate to patterns of electrical activity. One component of these long-term changes is …

During early neuronal development, GABA functions as an excitatory neurotransmitter,
triggering membrane depolarization, action potentials, and the opening of plasma …

Brain-derived neurotrophic factor (BDNF) is an important mediator of activity-dependent
functions of the nervous system and its expression is dysregulated in several …

The use of different brain-derived neurotrophic factor (BDNF) gene promoters results in the
differential production of 5′-alternative transcripts, suggesting versatile functions of BDNF …

It has been recently described that in embryonic stem cells, the expression of some
important developmentally regulated genes is repressed, but poised for fast activation under …

In the adult rat forebrain, brain-derived neurotrophic factor (BDNF) expression is very rapidly
induced by neuronal activity, suggesting that this might occur without intervening protein …