Dormant, disseminated breast cancer cells resist treatment and may relapse into malignant
metastases after decades of quiescence. Identifying how and why these dormant breast …

Breast cancer recurrence and metastasis from activated dormant tumors remain the leading
causes in disease morbidity. Women with estrogen receptor–positive breast cancer that …

The pattern of delayed recurrence in a subset of breast cancer patients has long been
explained by a model that incorporates a variable period of cellular or tumor mass dormancy …

Late recurrences of breast cancer are hypothesized to originate from disseminated tumor
cells that re‐activate after a long period of dormancy,≥ 5 years for estrogen‐receptor …

Simple Summary Breast cancer can return many years after treatment of the primary tumour.
This is caused by cells that have spread to other parts of the body and entered a non …

Background Breast cancer mortality is principally due to tumor recurrence, which can occur
following extended periods of clinical remission that may last decades. While clinical latency …

Tumor dormancy describes a prolonged quiescent state in which tumor cells are present, but
disease progression is not yet clinically apparent. Breast cancer is especially known for long …

Mortality of patients with breast cancer is due overwhelmingly to metastatic spread of the
disease. Although dissemination is an early event in breast cancer, extended periods of …

Breast cancer is a leading cause of global cancer‐related deaths, and metastasis is the
overwhelming culprit of poor patient prognosis. The most nefarious aspect of metastasis is …

Tumors can undergo long periods of dormancy, with cancer cells entering a largely
quiescent, non-proliferative state before reactivation and outgrowth. For a patient, these post …