Cancer development is characterized by chromosomal instability, manifesting in frequent
occurrences of different genomic alteration mechanisms ranging in extent and impact …

Chromosomal instability (CIN) refers to an increased rate of chromosomal changes within
cells. It is highly prevalent in cancer cells and leads to abnormalities in chromosome number …

Many cancers display whole chromosome instability (W-CIN) and structural chromosomal
instability (S-CIN), referring to increased rates of acquiring numerically and structurally …

Chromosomal instability (CIN), an increased rate of chromosome segregation errors during
mitosis, is a hallmark of cancer cells. CIN leads to karyotype differences between cells and …

Chromosomal instability (CIN) drives the formation of karyotype aberrations in cancer cells
and is a major contributor to intra-tumour heterogeneity, metastasis, and therapy resistance …

Numerical chromosomal instability is a ubiquitous feature of human neoplasms. Due to
experimental limitations, fundamental characteristics of karyotypic changes in cancer are …

Chromosomal instability is the process of mis-segregation for ongoing chromosomes, which
leads to cells with an abnormal number of chromosomes, also known as an aneuploid state …

Cancer research relies on model systems, which reflect the biology of actual human tumours
to only a certain extent. One important feature of human cancer is its intra-tumour genomic …

Cancer cells differ from healthy cells by genetic information that is massively altered not only
by point mutations and small insertions and deletions, but also by large scale changes such …

Large-scale, massively parallel sequencing of human cancer samples has revealed
tremendous genetic heterogeneity within individual tumors. Indeed, tumors are composed of …