Surface functionalization strategies of synthetic materials for regenerative medicine
applications comprise the development of microenvironments that recapitulate the physical …

Tissue engineering aims to regenerate new biological tissue for replacing diseased or
injured tissues. We propose a new approach to accelerate the deposition of cell-secreted …

Integrin clustering, typically nanometers in dimension, is the first and an important step in
integrin-mediated cellular signaling processes such as focal adhesion. Engineered …

Considering that vitronectin (VN) can promote both cell adhesion and matrix degradation, it
is likely to play a dual role at the cell-biomaterial interface. In this paper we therefore …

Cells regulate adhesion to the fibrillar extracellular matrix (ECM) of which fibronectin is an
essential component. However, most studies characterize cell adhesion to globular …

Modern innovation in reconstructive medicine implies the proposition of material-based
strategies suitable for tissue repair and regeneration. The development of such systems …

Mesenchymal stem cells (MSCs) are a research tool to investigate fundamental biology and
are candidates for use in regenerative medicine. In this context, significant efforts have been …

Engineering biomaterials for regenerative medicine involves a myriad of aspects to be
considered for the successful design, interaction with cells and integration with living tissues …

We present a detailed characterization of fibronectin (FN) adsorption and cell adhesion on
poly (ethyl acrylate)(PEA) and poly (methyl acrylate)(PMA), two polymers with very similar …

Biomaterial surface chemistry engenders profound consequences on cell adhesion and the
ultimate tissue response by adsorbing proteins from extracellular matrix, where vitronectin …