Brain changes after spinal cord injury, a quantitative meta-analysis and review

LS Dahlberg, L Becerra, D Borsook… - … & Biobehavioral Reviews, 2018 - Elsevier
Abstract Spinal Cord Injuries (SCI) lead to alterations in brain structure and brain function by
direct effects of nerve damage, by secondary mechanisms, and also by longer term injury …

Tracking changes following spinal cord injury: insights from neuroimaging

P Freund, A Curt, K Friston… - The Neuroscientist, 2013 - journals.sagepub.com
Traumatic spinal cord injury is often disabling and recovery of function is limited. As a
consequence of damage, both spinal cord and brain undergo anatomical and functional …

Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

G David, S Mohammadi, AR Martin… - Nature Reviews …, 2019 - nature.com
Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …

Progressive neurodegeneration following spinal cord injury: implications for clinical trials

G Ziegler, P Grabher, A Thompson, D Altmann… - Neurology, 2018 - AAN Enterprises
Objective To quantify atrophy, demyelination, and iron accumulation over 2 years following
acute spinal cord injury and to identify MRI predictors of clinical outcomes and determine …

Cortical morphometric changes after spinal cord injury

R Nardone, Y Höller, L Sebastianelli, V Versace… - Brain Research …, 2018 - Elsevier
Neuroimaging studies suggest that spinal cord injury (SCI) may lead to significant
anatomical alterations in the human sensorimotor system. In particular, voxel-based …

Disability, atrophy and cortical reorganization following spinal cord injury

P Freund, N Weiskopf, NS Ward, C Hutton, A Gall… - Brain, 2011 - academic.oup.com
The impact of traumatic spinal cord injury on structural integrity, cortical reorganization and
ensuing disability is variable and may depend on a dynamic interaction between the severity …

Tracking sensory system atrophy and outcome prediction in spinal cord injury

P Grabher, MF Callaghan, J Ashburner… - Annals of …, 2015 - Wiley Online Library
Objective In patients with subacute spinal cord injury (SCI), the motor system undergoes
progressive structural changes rostral to the lesion, which are associated with motor …

Longitudinal changes of spinal cord grey and white matter following spinal cord injury

G David, D Pfyffer, K Vallotton, N Pfender… - Journal of Neurology …, 2021 - jnnp.bmj.com
Objectives Traumatic and non-traumatic spinal cord injury produce neurodegeneration
across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and …

Guidelines for the conduct of clinical trials in spinal cord injury: neuroimaging biomarkers

M Seif, CAM Gandini Wheeler-Kingshott… - Spinal Cord, 2019 - nature.com
Traumatic spinal cord injury (SCI) leads to immediate neuronal and axonal damage at the
focal injury site and triggers secondary pathologic series of events resulting in sensorimotor …

Brain sensorimotor system atrophy during the early stage of spinal cord injury in humans

JM Hou, RB Yan, ZM Xiang, H Zhang, J Liu, YT Wu… - Neuroscience, 2014 - Elsevier
Spinal cord injury (SCI) usually leads to severe sensory and motor deficits below the spinal
lesion. Previous animal models have shown significant atrophic changes in the neural …