Aging is associated with a deterioration of cognitive performance and with increased risk of
neurodegenerative disorders. In the present study we tested whether the specific …

The senescence accelerated mouse-prone 8 (SAMP8) strain of mice is an experimental
model of accelerated senescence that also shares several pathological features with …

BACKGROUND AND PURPOSE Inhibitors of phosphodiesterase 5 (PDE5) affect signalling
pathways by elevating cGMP, which is a second messenger involved in processes of …

Age-related cognitive decline is accompanied by an increase of neuronal apoptosis and a
dysregulation of neuroplasticity-related molecules such as brain-derived neurotrophic factor …

Aging is characterized by a progressive cognitive decline that leads to memory impairment.
Because the cyclic nucleotide cascade is essential for the integrity of synaptic function and …

Nitric oxide/cyclic guanosine monophosphate (cGMP) signaling is compromised in
Alzheimer's disease (AD), and phosphodiesterase 5 (PDE5), which degrades cGMP, is …

Elevated levels of amyloid beta (Aβ) peptide, hyperphosphorylation of tau protein, and
inflammation are pathological hallmarks in Alzheimer's disease (AD). Phosphodiesterase 7 …

Ageing is associated with a deterioration of cognitive performance and with increased risk of
neurodegenerative disorders. Hypertension is the most-prevalent modifiable risk factor for …

The senescence-accelerated mouse prone-8 (SAMP8) model has been considered as a
good model for aged-related cognitive decline and Alzheimer's disease (AD). Since …

Background and purpose: In this study, we employed a multiple microinfarction (MMI) based
vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil …