Despite the discovery of the tuberculosis (TB) bacillus over 100 years ago and the
availability of effective drugs for over 50 years, there remain a number of formidable …

M ycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system
before the initiation of an adaptive immune response. This innate protection requires a …

In 2015, there were an estimated 10.4 million new cases of tuberculosis (TB) globally,
making it one of the leading causes of death due to an infectious disease. TB is caused by …

Mycobacterium tuberculosis (Mtb) has evolved within the human immune system as both
host and reservoir. The study of genes required for its growth and persistence in vivo thus …

The innate immune system provides the first response to infection and is now recognized to
be partially pathogen-specific. Mycobacterium tuberculosis (MTB) is able to subvert the …

Macrophages are the primary host cells for Mycobacterium tuberculosis, the causative agent
of tuberculosis (TB), during its intracellular survival in humans. The pathogen has a …

Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

Tuberculosis (TB) is a major public health problem. One-third of the world's population is
estimated to be infected with Mycobacterium tuberculosis (MTB), the etiological agent …

Although host genetics influences susceptibility to tuberculosis (TB), few genes determining
disease outcome have been identified. We hypothesized that macrophages from individuals …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …