In this review, we discuss sympathetic regulation in normal and diabetic wound healing.
Experimental denervation studies have confirmed that sympathetic nerve endings in skin …

The involvement of peripheral nerves in dermal wound healing, particularly in the
inflammatory response has not been extensively studied. Therefore, this study was …

Importance of the field: In 2010, the world prevalence of diabetes is 6.4%, affecting 285
million adults. Diabetic patients are at risk of developing neuropathy and delayed wound …

Lower extremity ulcerations represent a major complication in diabetes mellitus and involve
multiple physiological factors that lead to impairment of wound healing. Neuropeptides are …

Angiogenesis is essential for wound healing, and angiogenesis impairment can result in
chronic ulcers. Studies have shown that the sympathetic nervous system has an important …

The skin is densely innervated with an intricate network of cutaneous nerves,
neuromediators and specific receptors which influence a variety of physiological and …

Impaired wound healing is a significant clinical, economic, and social problem. There is a
growing body of research over the past several decades that supports the importance of …

Cutaneous wound healing is a normal physiological process and comprises different
phases. Among these phases, angiogenesis or new blood vessel formation in wound tissue …

Sympathetic nerve failure has been proposed as a contributing factor in impaired cutaneous
wound healing in diabetes mellitus. Nevertheless, no studies have shown whether β …

Type 2 diabetes is associated with several potential comorbidities, among them impaired
wound healing, chronic ulcerations, and the requirement for lower extremity amputation …