Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

Type 1 diabetes (T1D) is an autoimmune disease for which there is no cure. The pancreatic
beta cells are the source of insulin that keeps blood glucose normal. When susceptible …

There are three prerequisites for development of the autoimmune disease type 1 diabetes
(T1D). First, β cell-reactive T cells need to be activated; second, the response needs to be …

T cell-directed immunosuppression only transiently delays the loss of β cell function in
recent-onset type 1 diabetes. We argue here that the underlying disease process is carried …

During the past one to two decades, substantial progress has been made in our
understanding of the immunopathology of type 1 diabetes (T1D) and the potential for …

Advances in our fundamental understanding of how the human diabetes immune response
is activated and regulated coupled with lessons that have been learnt from the most recent …

Summary Type 1 diabetes (T1D) develops when there are insufficient insulin-producing beta
cells to maintain glucose homeostasis. The prevailing view has been that T1D is caused by …

Type 1 diabetes mellitus (T1DM) results from death of insulin-secreting β cells mediated by
self-immune cells, and the consequent inability of the body to maintain insulin levels for …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss
of insulin-producing pancreatic β-cells. The pathogenesis of T1D is complex and …

Type 1 diabetes (T1D) is a chronic autoimmune disease that leads to destruction of
pancreatic β cells, lifelong dependence on insulin, and increased morbidity and mortality …