Hematopoietic stem and progenitor cells (HSPCs) can give rise to all kinds of immune cells
including neutrophils. Neutrophils are the first line of defense in the innate immune system …

Hematopoietic stem and progenitor cells (HSPCs) respond to infection by proliferating and
generating in-demand neutrophils through a process called emergency granulopoiesis …

Recent studies suggest that infection reprograms hematopoietic stem and progenitor cells
(HSPCs) to enhance innate immune responses upon secondary infectious challenge, a …

Hematopoietic stem and progenitor cells (HSPCs) respond to infection by proliferating and
generating in-demand neutrophils through a process called emergency granulopoiesis …

Recent evidence shows that innate immune cells, in addition to B and T cells, can retain
immunological memory of their encounters and afford long-term resistance against …

Hematopoiesis is hierarchically orchestrated by a very small population of hematopoietic
stem cells (HSCs) that reside in the bone-marrow niche and are tightly regulated to maintain …

Neutrophils, the most abundant white blood cells in human blood circulation, play a critical
element of the innate immune response that forms the first line of defense against invading …

Pathogen-initiated chronic inflammation or autoimmune diseases accelerate proliferation
and promote differentiation of hematopoietic stem cells (HSCs) but simultaneously reduce …

Neutrophils are critical mediators during the early stages of innate inflammation in response
to bacterial or fungal infections. A human hematopoietic system reconstituted in humanized …

More mechanistic studies are needed to reveal the hidden details of in vivo-induced trained
immunity. Here, using a Candida albicans live vaccine mouse model we show that …