[HTML][HTML] IgG4 antibodies induced by repeated vaccination may generate immune tolerance to the SARS-CoV-2 spike protein

VN Uversky, EM Redwan, W Makis, A Rubio-Casillas - Vaccines, 2023 - mdpi.com
Less than a year after the global emergence of the coronavirus SARS-CoV-2, a novel
vaccine platform based on mRNA technology was introduced to the market. Globally, around …

[HTML][HTML] Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history

P Kiszel, P Sík, J Miklós, E Kajdácsi, G Sinkovits… - Scientific Reports, 2023 - nature.com
Vaccinations against SARS-CoV-2 reduce the risk of developing serious COVID-19 disease.
Monitoring spike-specific IgG subclass levels after vaccinations may provide additional …

Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination

P Irrgang, J Gerling, K Kocher, D Lapuente… - Science …, 2022 - science.org
RNA vaccines are efficient preventive measures to combat the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) pandemic. High levels of neutralizing SARS-CoV-2 …

[HTML][HTML] Human IgG and IgA responses to COVID-19 mRNA vaccines

AV Wisnewski, JC Luna, CA Redlich - PloS one, 2021 - journals.plos.org
SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral
neutralization and are likely an important component of natural immunity, however, limited …

Is it bad, is it good, or is IgG4 just misunderstood?

S Pillai - Science Immunology, 2023 - science.org
Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-
spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed …

[HTML][HTML] SARS-CoV-2 vaccination elicits unconventional IgM specific responses in naïve and previously COVID-19-infected individuals

A Ruggiero, C Piubelli, L Calciano, S Accordini… - …, 2022 - thelancet.com
Background Currently, evaluation of the IgG antibodies specific for the SARS-CoV-2 Spike
protein following vaccination is used worldwide to estimate vaccine response. Limited data …

[HTML][HTML] mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses …

JS Buhre, T Pongracz, I Künsting, AS Lixenfeld… - Frontiers in …, 2023 - frontiersin.org
Background The new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and
mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS …

Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies

M Zendt, FA Bustos Carrillo, S Kelly, T Saturday… - Science …, 2023 - science.org
Research on coronavirus disease 2019 vaccination in immune-deficient/disordered people
(IDP) has focused on cancer and organ transplantation populations. In a prospective cohort …

[HTML][HTML] First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in subjects who have recovered from COVID-19

A Mazzoni, N Di Lauria, L Maggi… - The Journal of …, 2021 - Am Soc Clin Investig
The characterization of the adaptive immune response to COVID-19 vaccination in
individuals who recovered from SARS-CoV-2 infection may define current and future clinical …

Differences in IgG antibody responses following BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines

JG Montoya, AE Adams, V Bonetti, S Deng… - Microbiology …, 2021 - Am Soc Microbiol
Studies examining antibody responses by vaccine brand are lacking and may be informative
for optimizing vaccine selection, dosage, and regimens. The purpose of this study is to …