Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell
growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is …

Aerobic life consumes oxygen for efficient production of high energy compounds. The ability
to sense and respond to changes in oxygen partial pressure represents a fundamental …

The hypoxia-inducible factor (HIF-1), in addition to genetic and epigenetic changes, is
largely responsible for alterations in cell metabolism in hypoxic tumour cells. This …

Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function,
but is also an important component of the tumour microenvironment as it alters the …

Tumour hypoxia stems from impaired oxygen delivery as a result of a disorganised tumour
vasculature and inadequate blood supply. Hypoxic tumours are highly resistant to …

Both tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent
analyses have revealed complex interconnections between oncogenic activation, hypoxia …

Several decades of scientific observations followed by years of basic and now clinical
research support the notion that the metabolic power of tumor cells can provide the long …

Hypoxic microenvironments frequently exist in many solid tumours with oxygen levels
fluctuating temporally and spatially from normoxia to hypoxia. The response to hypoxia in …

Oxygen deprivation leading to hypoxia is a common feature of solid tumours. Under these
conditions a signalling pathway involving a key oxygen-response regulator termed the …

Hypoxia is a hallmark of the tumor microenvironment and contributes to tumor malignant
phenotypes. Hypoxia-inducible factor (HIF) is a master regulator of intratumoral hypoxia and …