Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and
Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition …

Loss of PTEN is a common event in many cancers and leads to hyperactivation of the PI3K–
AKT signaling pathway. The mechanisms by which AKT isoforms mediate signaling to …

Although the prognosis of patients with localized prostate cancer is good after surgery, with
a favorable response to androgen deprivation therapy, about one third of them invariably …

Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the
phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic …

Prostate cancer remains a major cause of cancer-related mortality. Genetic clues to the
molecular pathways driving the most aggressive forms of prostate cancer have been limited …

We analyzed the PI3K-AKT signaling cascade in a cohort of sarcomas and found a marked
induction of insulin receptor substrate-2 (IRS2) and phosphorylated AKT and a concomitant …

Background Despite significant advances in molecular characterization and therapeutic
targeting of advanced prostate cancer, it remains the second most common cause of cancer …

The phosphatidylinositol 3-kinase/Akt pathway plays a critical role in oncogenesis, and
dysregulation of this pathway through loss of PTEN suppression is a particularly common …

Genetic alterations targeting the PTEN tumor suppressor gene are among the most
frequently noted somatic mutations in human cancers. Such lesions have been noted in …

Loss of the PTEN tumour suppressor is one of the most common oncogenic drivers across
all cancer types. PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform …