With advances in basic and clinical neuroscience, many gaps have appeared in the
traditional monoamine theory of depression that have led to reformulation of the hypotheses …

In the last few years, there have been several advances in the determination of the role of
the endocannabinoid system in the etiology of depression and the functional actions of …

The present review synthetically describes the currently advanced hypotheses for a
neurobiological basis of depression, ranging from the classical monoaminergic to the more …

The endocannabinoid system is a neuromodulatory system which is known to regulate
emotional, cognitive, neurovegetative and motivational processes. Substantial evidence has …

It has been suggested that disturbances in endocannabinoid signaling contribute to the
development of depressive illness; however, at present there is insufficient evidence to allow …

Mental disorders have a high prevalence compared with many other health conditions and
are the leading cause of disability worldwide. Several studies performed in the last years …

Background: Preclinical research has suggested that the endocannabinoid system may be
involved in the etiology and/or treatment of depression; however, there are no published …

Cannabinoids are well known modulators of mood and emotional behavior. Current
research supports a role for endocannabinoid signaling in the treatment of depression …

Ashton CH, Moore PB. Endocannabinoid system dysfunction in mood and related disorders.
Objective: The endocannabinoid (EC) system is widely distributed throughout the brain and …

Major depressive disorder is a high-impact, debilitating disease and it is currently
considered the most prevalent mental illness. It is associated with disability, as well as …