Gene therapy holds great promise for various medical and biomedical applications. Nonviral
gene delivery systems formed by cationic polymer and nucleic acids (eg, polyplexes) have …

Intracellular nucleic acid delivery has the potential to treat many genetically-based diseases,
however, gene delivery safety and efficacy remains a challenging obstacle. One promising …

Nanoparticle-based delivery systems have contributed to the recent clinical success of RNA
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …

Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …

The nonviral delivery of exogenous nucleic acids (NA) into cells for therapeutic purposes
has rapidly matured into tangible clinical impact. Synthetic polymers are particularly …

Polymers present an interesting option for the delivery of genes and other therapeutic
nucleic acids. In the delivery process, the polymeric carriers face many different delivery …

Cationic polymer gene delivery vehicles that effectively resist premature serum degradation
often have difficulty releasing their nucleic acid cargoes. In this work, we report a pH …

As an option for genetic disease treatment and an alternative for traditional cancer
chemotherapy, gene therapy achieves significant attention. Nucleic acid delivery, however …

The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …