The good, the bad and the new about uric acid in cancer

S Allegrini, M Garcia-Gil, R Pesi, M Camici, MG Tozzi - Cancers, 2022 - mdpi.com
Simple Summary The concentration of uric acid in blood is sex-, age-and diet-dependent
and is maintained close to its maximal solubility, indicating that it plays some important role …

[HTML][HTML] Friend or foe? An unrecognized role of uric acid in cancer development and the potential anticancer effects of uric acid-lowering drugs

S Mi, L Gong, Z Sui - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
In recent years, metabolic syndrome (Mets) has been a hot topic among medical scientists.
Mets has an intimate relationship with the incidence and development of various cancers. As …

Contribution of uric acid to cancer risk, recurrence, and mortality

MA Fini, A Elias, RJ Johnson, RM Wright - Clinical and translational …, 2012 - Springer
Two risk factors for the development and progression of cancers that are amenable to life
style modification are chronic inflammation and the metabolic syndrome. This review …

What is the biological function of uric acid? An antioxidant for neural protection or a biomarker for cell death

D Liu, Y Yun, D Yang, X Hu, X Dong, N Zhang… - Disease …, 2019 - Wiley Online Library
The main aim of the present study was to investigate the biological function of uric acid. The
level of uric acid in different organs in normal male rats was determined with uric acid assay …

High serum uric acid concentration predicts poor survival in patients with breast cancer

CF Yue, PN Feng, ZR Yao, XG Yu, W Lin, YM Qian… - Clinica Chimica …, 2017 - Elsevier
Background Uric acid is a product of purine metabolism. Recently, uric acid has gained
much attraction in cancer. In this study, we aim to investigate the clinicopathological and …

Serum uric acid increases risk of cancer incidence and mortality: a systematic review and meta‐analysis

S Yan, P Zhang, W Xu, Y Liu, B Wang… - Mediators of …, 2015 - Wiley Online Library
SUA is a potent antioxidant and thus may play a protective role against cancer. Many
epidemiological studies have investigated this hypothesis but provided inconsistent and …

[HTML][HTML] The role of serum uric acid as an antioxidant protecting against cancer: prospective study in more than 28 000 older Austrian women

AM Strasak, K Rapp, W Hilbe, W Oberaigner… - Annals of …, 2007 - Elsevier
Background: It has been hypothesized that serum uric acid (SUA), via its antioxidant
properties may protect against carcinogenesis. However, few epidemiological investigations …

Hyperuricemia and gout are associated with cancer incidence and mortality: a meta‐analysis based on cohort studies

Y Xie, P Xu, K Liu, S Lin, M Wang, T Tian… - Journal of cellular …, 2019 - Wiley Online Library
The association between hyperuricemia or gout and cancer risk has been investigated in
various published studies, but their results are conflicting. We conducted a meta‐analysis to …

Uric acid and cardiovascular disease

G Ndrepepa - Clinica chimica acta, 2018 - Elsevier
Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Serum uric acid and cancer mortality and incidence: a systematic review and meta-analysis

F Dovell, P Boffetta - European Journal of Cancer Prevention, 2018 - journals.lww.com
Elevated serum uric acid (SUA) is a marker of chronic inflammation and has been suggested
to be associated with increased risk of cancer, but its antioxidant capacity would justify an …