[HTML][HTML] Modeling human ectopic pregnancies with trophoblast and vascular organoids

X Zhao, Z Zhang, Q Zhu, Y Luo, Q Ye, S Shi, X He… - Cell Reports, 2023 - cell.com
Ruptured ectopic pregnancy (REP), a pregnancy complication caused by aberrant
implantation, deep invasion, and overgrowth of embryos in fallopian tubes, could lead to …

Colony‐stimulating factor 1 positive (CSF1+) secretory epithelial cells induce excessive trophoblast invasion in tubal pregnancy rupture

X Zhao, L Yan, S Ji, Y Zhang, L Ha, C He… - Cell …, 2023 - Wiley Online Library
Tubal ectopic pregnancy (TEP) occurs when an embryo aberrantly implants in the fallopian
tube, leading to abortive or ruptured tubal ectopic pregnancy (AEP or REP). Poor outcomes …

Development and characterization of human fetal female reproductive tract organoids to understand Müllerian duct anomalies

VD Venkata, MFB Jamaluddin, J Goad… - Proceedings of the …, 2022 - National Acad Sciences
Müllerian ducts are paired tubular structures that give rise to most of the female reproductive
organs. Any abnormalities in the development and differentiation of these ducts lead to …

Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling

J Cha, A Bartos, C Park, X Sun, Y Li, SW Cha, R Ajima… - Cell reports, 2014 - cell.com
Embryo homing and implantation occur within a crypt (implantation chamber) at the
antimesometrial (AM) pole along the uterus. The mechanism by which this is achieved is not …

[PDF][PDF] A blood vessel organoid model recapitulating aspects of vasculogenesis, angiogenesis and vessel wall maturation. Organoids. 2022: 1 (1): 41–53

S Schmidt, Y Alt, N Deoghare, S Krüger, A Kern… - 2022 - researchgate.net
Blood vessel organoids are an important in vitro model to understand the underlying
mechanisms of human blood vessel development and for toxicity testing or high throughput …

Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells

H Wang, PC Charles, Y Wu, R Ren, X Pi… - Circulation …, 2006 - Am Heart Assoc
We have used global gene expression analysis to establish a comprehensive list of
candidate genes in the developing vasculature during embryonic (ES) cell differentiation in …

A blood vessel organoid model recapitulating aspects of vasculogenesis, angiogenesis and vessel wall maturation

S Schmidt, Y Alt, N Deoghare, S Krüger, A Kern… - Organoids, 2022 - mdpi.com
Blood vessel organoids are an important in vitro model to understand the underlying
mechanisms of human blood vessel development and for toxicity testing or high throughput …

First trimester trophoblasts forming endothelial-like tubes in vitro emulate a 'blood vessel development'gene expression profile

AR Highet, S Buckberry, BT Mayne, SM Khoda… - Gene expression …, 2016 - Elsevier
Extravillous cytotrophoblasts isolated from first trimester placenta, and immortalised cell
lines derived from them, have the intrinsic ability to form endothelial-like tubes when cultured …

Engineering placenta‐like organoids containing endogenous vascular cells from human‐induced pluripotent stem cells

K Cui, T Chen, Y Zhu, Y Shi, Y Guo… - … & Translational Medicine, 2023 - Wiley Online Library
The placenta is an essential organ that maintains the health of both the fetus and its mother.
Understanding the development of human placenta has been hindered by the limitations of …

Generation of 3D trophoblast organoids from human naïve pluripotent stem cells

RM Karvas, TW Theunissen - Embryo Models In Vitro: Methods and …, 2023 - Springer
The human placenta is a transient organ that functions to support the needs of the fetus
throughout gestation. Trophoblasts are the major epithelial cells found within the placenta …