Seizure burden and neurodevelopmental outcome in neonates with hypoxic–ischemic encephalopathy

L Kharoshankaya, NJ Stevenson… - … Medicine & Child …, 2016 - Wiley Online Library
Aim To examine the relationship between electrographic seizures and long‐term outcome in
neonates with hypoxic–ischemic encephalopathy (HIE). Method Full‐term neonates with HIE …

Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the …

JM Kwon, R Guillet, S Shankaran… - Journal of child …, 2011 - journals.sagepub.com
It remains controversial as to whether neonatal seizures have additional direct effects on the
developing brain separate from the severity of the underlying encephalopathy. Using data …

The temporal evolution of electrographic seizure burden in neonatal hypoxic ischemic encephalopathy

NE Lynch, NJ Stevenson, V Livingstone, BP Murphy… - …, 2012 - Wiley Online Library
Purpose: Hypoxic ischemic encephalopathy (HIE) accounts for 60% of all neonatal seizures.
There is emerging evidence that seizures cause additional injury to the developing brain …

Role of EEG background activity, seizure burden and MRI in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischaemic encephalopathy in the …

LC Weeke, GB Boylan, RM Pressler, B Hallberg… - European Journal of …, 2016 - Elsevier
Objective To investigate the role of EEG background activity, electrographic seizure burden,
and MRI in predicting neurodevelopmental outcome in infants with hypoxic-ischaemic …

Treating EEG seizures in hypoxic ischemic encephalopathy: a randomized controlled trial

P Srinivasakumar, J Zempel, S Trivedi… - …, 2015 - publications.aap.org
BACKGROUND: The impact of treating electrographic seizures in hypoxic ischemic
encephalopathy (HIE) is unknown. METHODS: Neonates≥ 36 weeks with moderate or …

Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years

DM Murray, GB Boylan, CA Ryan, S Connolly - Pediatrics, 2009 - publications.aap.org
OBJECTIVE: We examined the evolution of electroencephalographic (EEG) changes after
hypoxic injury. METHODS: Continuous, multichannel, video-EEG was recorded for term …

Development of epilepsy in newborns with moderate hypoxic-ischemic encephalopathy and neonatal seizures

F Pisani, M Orsini, S Braibanti, C Copioli, L Sisti… - Brain and …, 2009 - Elsevier
Background: Hypoxic-ischemic encephalopathy (HIE) is one of the most frequent causes of
neonatal death or neurological handicaps such as cerebral palsy, mental delay, and …

Electrographic seizures are associated with brain injury in newborns undergoing therapeutic hypothermia

DK Shah, CJ Wusthoff, P Clarke, JS Wyatt… - Archives of Disease in …, 2014 - fn.bmj.com
Objective Seizures are common among newborns with hypoxic-ischaemic encephalopathy
(HIE) but the relationship between seizure burden and severity of brain injury among …

Therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy: electrographic seizures and magnetic resonance imaging evidence of injury

P Srinivasakumar, J Zempel, M Wallendorf… - The Journal of …, 2013 - Elsevier
Objective To evaluate the electrographic seizure burden in neonates with hypoxic ischemic
encephalopathy (HIE) treated with or without therapeutic hypothermia and stratified results …

Early EEG grade and outcome at 5 years after mild neonatal hypoxic ischemic encephalopathy

DM Murray, CM O'Connor, CA Ryan… - …, 2016 - publications.aap.org
OBJECTIVE: More than half of all infants with neonatal hypoxic ischemic encephalopathy
(HIE) are graded as mild and do not meet current criteria for therapeutic hypothermia. These …