B cells obtain help from T cells in the antibody response by acting as antigen-specific
antigen presenting cells. A direct signal through binding of antigen to membrane Ig can …

Publisher Summary This chapter reviews the evidence in favor of the concept that B cells
can serve as antigen-presenting accessory cells to T cells of the helper/inducer subset as …

Activation of B cells to proliferation and antibody secretion is dependent on soluble
lymphokines secreted by activated T cells. Activation of T cells results from physical contact …

Th physically interact with B cells and produce lymphokines that influence B cell growth and
differentiation. The respective contribution of cell contact and lymphokines to induction of B …

Publisher Summary This chapter discusses the interactions between T and B cells and the
role of accessory cells and cytokines in the generation of specific antibody responses. The …

Cellular interactions involved in the T cell-dependent activation of B cells were analyzed by
using lines and clones of helper T cells specific for determinants expressed on the B cell …

CD4+ T lymphocytes provide contact-dependent stimuli to B cells that are critical for the
generation of specific antibody responses in a process termed T helper function. The surface …

Activated Th cells deliver contact-dependent signals to resting B lymphocytes that initiate
and drive B cell proliferation. Recently, a ligand for the B lymphocyte membrane protein …

Publisher Summary This chapter discusses the intimate mechanisms of the regulation of
antibody responses by T cells, the significance of these phenomena for the regulatory …

The activation of B lymphocytes from the resting stage to the proliferating stage and then to
the fully differentiated antibody-secreting stage is a highly regulated and complicated …