[HTML][HTML] Serotonin and Dopamine Protect from Hypothermia/Rewarming Damage through the CBS/ H2S Pathway

F Talaei, HR Bouma, AC Van der Graaf, AM Strijkstra… - PLoS …, 2011 - journals.plos.org
Biogenic amines have been demonstrated to protect cells from apoptotic cell death. Herein
we show for the first time that serotonin and dopamine increase H2S production by the …

Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming–The role of renal H2S-producing enzymes

GJ Dugbartey, F Talaei, MC Houwertjes, M Goris… - European Journal of …, 2015 - Elsevier
Hypothermia and rewarming produces organ injury through the production of reactive
oxygen species. We previously found that dopamine prevents hypothermia and rewarming …

The heat shock response and small molecule regulators

MK Kurop, CM Huyen, JH Kelly, BSJ Blagg - European journal of medicinal …, 2021 - Elsevier
The heat shock response (HSR) is a highly conserved cellular pathway that is responsible
for stress relief and the refolding of denatured proteins [1]. When a host cell is exposed to …

[HTML][HTML] Hydrogen sulphide and mild hypothermia activate the CREB signaling pathway and prevent ischemia-reperfusion injury

H Dai, X Ji, S Zhu, Y Hu, L Zhang, X Miao, RM Ma… - BMC …, 2015 - Springer
Background Both hydrogen sulphide (H 2 S) and mild hypothermia have been reported to
prevent brain damage caused by reperfusion assault through regulating the N-methyl-D …

Hypothermic injury: the mitochondrial calcium, ATP and ROS love-hate triangle out of balance

PT Brinkkoetter, H Song, R Lösel… - Cellular physiology and …, 2008 - karger.com
Abstract Background/Aims: Catecholamines prevent hypothermic cell death which accounts
for severe tissue damage and impaired allograft function after prolonged organ preservation …

Melatonin attenuates MPP+-induced apoptosis via heat shock protein in a Parkinson's disease model

YJ Jung, H Choi, E Oh - Biochemical and Biophysical Research …, 2022 - Elsevier
Heat shock proteins (HSPs) play an essential role as molecular chaperones to prevent
abnormal protein aggregation and misfolding. Moreover, they protect dopamine neurons …

[HTML][HTML] Hypothermia alleviates reductive stress, a root cause of ischemia reperfusion injury

KL Eskla, H Vellama, L Tarve, H Eichelmann… - International Journal of …, 2022 - mdpi.com
Ischemia reperfusion injury is common in transplantation. Previous studies have shown that
cooling can protect against hypoxic injury. To date, the protective effects of hypothermia …

Molecular and cellular pathways as a target of therapeutic hypothermia: pharmacological aspect

H Soo Han, J Park, JH Kim… - Current …, 2012 - ingentaconnect.com
Induced therapeutic hypothermia is the one of the most effective tools against brain injury
and inflammation. Even though its beneficial effects are well known, there are a lot of pitfalls …

Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation

Y Wang, R Yu, L Wu, G Yang - Cellular signalling, 2021 - Elsevier
Recognized as a novel and important gasotransmitter, hydrogen sulfide (H 2 S) is widely
present in various tissues and organs. Cystathionine gamma-lyase (CSE)-derived H 2 S has …

Hypothermia protects neurons against ischemia/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K/Akt/GSK-3β signaling pathway

MY Diao, Y Zhu, J Yang, SS Xi, X Wen, Q Gu… - Brain Research Bulletin, 2020 - Elsevier
Cerebral ischemia/reperfusion (I/R) injury often leads to irreversible neuronal injury and
even death, and hypothermia is the only therapeutic method that has been proven to be …