[HTML][HTML] Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …
[HTML][HTML] The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma
T Evan, VMY Wang, A Behrens - Oncogene, 2022 - nature.com
Intratumour heterogeneity (ITH) has become an important focus of cancer research in recent
years. ITH describes the cellular variation that enables tumour evolution, including tumour …
years. ITH describes the cellular variation that enables tumour evolution, including tumour …
A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma
A Hayashi, J Fan, R Chen, Y Ho, AP Makohon-Moore… - Nature cancer, 2020 - nature.com
Pancreatic cancer expression profiles largely reflect a classical or basal-like phenotype. The
extent to which these profiles vary within a patient is unknown. We integrated evolutionary …
extent to which these profiles vary within a patient is unknown. We integrated evolutionary …
[HTML][HTML] Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment
G Werba, D Weissinger, EA Kawaler, E Zhao… - Nature …, 2023 - nature.com
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a
complex ecosystem that drives tumor progression; however, in-depth single cell …
complex ecosystem that drives tumor progression; however, in-depth single cell …
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes
S Mueller, T Engleitner, R Maresch, M Zukowska… - Nature, 2018 - nature.com
The poor correlation of mutational landscapes with phenotypes limits our understanding of
the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we …
the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we …
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory
cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet …
cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet …
[HTML][HTML] Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis
S Zhang, W Fang, S Zhou, D Zhu, R Chen… - Nature …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease refractory to all
targeted and immune therapies. However, our understanding of PDAC microenvironment …
targeted and immune therapies. However, our understanding of PDAC microenvironment …
A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development. The current model of …
exemplifies the classically held view of stepwise cancer development. The current model of …
[HTML][HTML] Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance
MH Sherman, GL Beatty - Annual Review of Pathology …, 2023 - annualreviews.org
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …