The molecular mechanisms underlying atrial fibrillation (AF), the most common form of
arrhythmia, are poorly understood and therefore target-specific treatment options remain an …

Atrial fibrillation (AF) is the most prevalent and progressive cardiac arrhythmia worldwide
and is associated with serious complications such as heart failure and ischemic stroke …

Atrial fibrillation (AF), the most common progressive tachyarrhythmia, results in structural
remodeling which impairs electrical activation of the atria, rendering them increasingly …

Oxidative stress has been suggested to play a role in the pathogenesis of atrial fibrillation
(AF). Indeed, the prevalence of AF increases with age as does oxidative stress. However …

Mitochondria are essential to providing ATP, thereby satisfying the energy demand of the
incessant electrical activity and contractile action of cardiac muscle. Emerging evidence …

Mitochondria are critical for maintaining normal cardiac function, and a deficit in
mitochondrial energetics can lead to the development of the substrate that promotes atrial …

Accumulating evidence links calcium-overload and oxidative stress to atrial remodeling
during atrial fibrillation (AF). Furthermore, atrial remodeling appears to increase atrial …

Atrial cardiomyocytes are essential for fluid homeostasis, ventricular filling, and survival, yet
their cell biology and physiology are incompletely understood. It has become clear that the …

Cardiomyocytes are one of the most mitochondria-rich cell types in the body, with∼ 30–40%
of the cell volume being composed of mitochondria. Mitochondria are well established as …

Mitochondria have long been recognized for their central role in energy transduction and
apoptosis. More recently, extensive work in multiple laboratories around the world has …